04673cam a2200613Mi 4500001001300000003000600013005001700019006001900036007001500055008004100070020003600111020003300147020003600180020003300216020001800249020001500267029002100282029002100303029002300324029002300347029002100370029001800391035002100409040008300430049000900513050001100522072002500533082001400558245012900572260003500701300003500736336002600771337002600797338003600823490005900859504005100918505194000969520060602909588002603515650001603541650003603557650004203593655002203635700002603657700002303683700003003706700001903736700001903755776011903774830005103893856008403944942001204028999001904040ocn893739321OCoLC20171026095023.0m     o  d        cr cnu|||unuuu141025s2014    gw      ob    001 0 eng d  a9783527674183q(electronic bk.)  a3527674187q(electronic bk.)  a9783527674190q(electronic bk.)  a3527674195q(electronic bk.)  z9783527674206  z35276742091 aCHBISb0104417151 aCHVBKb3340914111 aDEBBGbBV0427942271 aDEBBGbBV0433972261 aDEBSZb4318010371 aNZ1b15910036  a(OCoLC)893739321  aEBLCPbengepncEBLCPdOCLCOdDG1dN$TdOHIdOCLCFdDEBSZdOCLCQdDEBBGdOCLCQ  aMAIN 4aRA1211 7aMEDx0710002bisacsh04a615.922300aPredictive toxicology : from vision to reality /cedited by Friedlieb Pfannkuch and Laura Suter-Dick.h[electronic resource]  aWeinheim :bWiley-VCH,c[2014]  a1 online resource (433 pages).  atextbtxt2rdacontent  acomputerbc2rdamedia  aonline resourcebcr2rdacarrier1 aMethods and Principles in Medicinal Chemistry ;vv. 64  aIncludes bibliographical references and index.0 aIntroduction to Predictive Toxicology Tools and Methods / Laura Suter-Dick, Friedlieb Pfannkuch -- Toxicology : Current Approaches and Future Perspectives to Predict Toxic Effects with Computational Tools / Thomas Steger-Hartmann -- Approaches: Data Management : Bioinformatics / Arnd Brandenburg, Hans Gmuender, Timo Wittenberger -- Role of Modeling and Simulation in Toxicology Prediction / Antje-Christine Walz, Hans Peter Grimm, Christophe Meille, Antonello Caruso, Neil Parrott, Thierry Lave -- Genomic Applications for Assessing Toxicities of Liver and Kidney Injury / Philip Hewitt, Esther Johann -- Use of Toxicogenomics for Mechanistic Characterization of Hepatocarcinogens in Shorter Term Studies / Heidrun Ellinger-Ziegelbauer -- Discovery and Application of Novel Biomarkers / Timothy W Gant, Emma L Marczylo, Martin O Leonard -- Predictive Toxicology: Genetics, Genomics, Epigenetics, and Next-Generation Sequencing in Toxicology / Tobias Heckel, Laura Suter-Dick -- Biomarkers as Tools for Predictive Safety Assessment: Novel Markers of Drug-Induced Kidney Injury / Angela Mally -- The Use of Renal Cell Culture for Nephrotoxicity Investigations / Anja Wilmes, Paul Jennings -- The Zebrafish Model in Toxicology / Natalie Mesens -- Predictive Method Development: Challenges for Cosmetics and Genotoxicity as a Case Study / Gladys Ouedraogo, Fabrice Nesslany, Sophie Simar, Smail Talahari, Doris Lagache, Eric Vercauteren, Lauren Nakab, Astrid Mayoux, Brigitte Faquet, Nicole Flamand -- Using Pluripotent Stem Cells and Their Progeny as an Model to Assess (Developmental) Neurotoxicity / Lisa Hoelting, Marcel Leist, Luc Stoppini -- Stem Cell-Based Methods for Identifying Developmental Toxicity Potential / Jessica A Palmer, Robert E Burrier, Laura A Egnash, Elizabeth LR Donley -- Immunogenicity of Protein Therapeutics: Risk Assessment and Risk Mitigation / Harald Kropshofer -- Regulatory Aspects / Beatriz Silva Lima.  aTailored to the needs of drug developers, this one-stop reference for medicinal chemists covers all the latest developments in the field of predictive toxicology and its applications in safety assessment. With a keen emphasis on novel approaches, the topics have been tackled by selected expert scientists, who are familiar with the theoretical scientific background as well as with the practical application of current methods. Emerging technologies in toxicity assessment are introduced and evaluated in terms of their predictive power, with separate sections on computer predictions and simulation.0 aPrint version record. 0aToxicology. 7aMEDICALxPharmacology.2bisacsh 7aToxicology.2fast0(OCoLC)fst01153364 4aElectronic books.1 aPfannkuch, Friedlieb.1 aSuter-Dick, Laura.1 aMannhold, Raimund,d1948-1 aKubinyi, Hugo.1 aFolkers, Gerd.08iPrint version:tPredictive Toxicology : From Vision to Reality, Volume 64.dHoboken : Wiley, ©2014z9783527336081 0aMethods and principles in medicinal chemistry.40uhttp://onlinelibrary.wiley.com/book/10.1002/9783527674183zWiley Online Library  2ddccBK  c207721d207721