04673cam a2200613Mi 4500 ocn893739321 OCoLC 20171026095023.0 m o d cr cnu|||unuuu 141025s2014 gw ob 001 0 eng d 9783527674183 (electronic bk.) 3527674187 (electronic bk.) 9783527674190 (electronic bk.) 3527674195 (electronic bk.) 9783527674206 3527674209 CHBIS 010441715 CHVBK 334091411 DEBBG BV042794227 DEBBG BV043397226 DEBSZ 431801037 NZ1 15910036 (OCoLC)893739321 EBLCP eng pn EBLCP OCLCO DG1 N$T OHI OCLCF DEBSZ OCLCQ DEBBG OCLCQ MAIN RA1211 MED 071000 bisacsh 615.9 23 Predictive toxicology : from vision to reality / edited by Friedlieb Pfannkuch and Laura Suter-Dick. [electronic resource] Weinheim : Wiley-VCH, [2014] 1 online resource (433 pages). text txt rdacontent computer c rdamedia online resource cr rdacarrier Methods and Principles in Medicinal Chemistry ; v. 64 Includes bibliographical references and index. Introduction to Predictive Toxicology Tools and Methods / Laura Suter-Dick, Friedlieb Pfannkuch -- Toxicology : Current Approaches and Future Perspectives to Predict Toxic Effects with Computational Tools / Thomas Steger-Hartmann -- Approaches: Data Management : Bioinformatics / Arnd Brandenburg, Hans Gmuender, Timo Wittenberger -- Role of Modeling and Simulation in Toxicology Prediction / Antje-Christine Walz, Hans Peter Grimm, Christophe Meille, Antonello Caruso, Neil Parrott, Thierry Lave -- Genomic Applications for Assessing Toxicities of Liver and Kidney Injury / Philip Hewitt, Esther Johann -- Use of Toxicogenomics for Mechanistic Characterization of Hepatocarcinogens in Shorter Term Studies / Heidrun Ellinger-Ziegelbauer -- Discovery and Application of Novel Biomarkers / Timothy W Gant, Emma L Marczylo, Martin O Leonard -- Predictive Toxicology: Genetics, Genomics, Epigenetics, and Next-Generation Sequencing in Toxicology / Tobias Heckel, Laura Suter-Dick -- Biomarkers as Tools for Predictive Safety Assessment: Novel Markers of Drug-Induced Kidney Injury / Angela Mally -- The Use of Renal Cell Culture for Nephrotoxicity Investigations / Anja Wilmes, Paul Jennings -- The Zebrafish Model in Toxicology / Natalie Mesens -- Predictive Method Development: Challenges for Cosmetics and Genotoxicity as a Case Study / Gladys Ouedraogo, Fabrice Nesslany, Sophie Simar, Smail Talahari, Doris Lagache, Eric Vercauteren, Lauren Nakab, Astrid Mayoux, Brigitte Faquet, Nicole Flamand -- Using Pluripotent Stem Cells and Their Progeny as an Model to Assess (Developmental) Neurotoxicity / Lisa Hoelting, Marcel Leist, Luc Stoppini -- Stem Cell-Based Methods for Identifying Developmental Toxicity Potential / Jessica A Palmer, Robert E Burrier, Laura A Egnash, Elizabeth LR Donley -- Immunogenicity of Protein Therapeutics: Risk Assessment and Risk Mitigation / Harald Kropshofer -- Regulatory Aspects / Beatriz Silva Lima. Tailored to the needs of drug developers, this one-stop reference for medicinal chemists covers all the latest developments in the field of predictive toxicology and its applications in safety assessment. With a keen emphasis on novel approaches, the topics have been tackled by selected expert scientists, who are familiar with the theoretical scientific background as well as with the practical application of current methods. Emerging technologies in toxicity assessment are introduced and evaluated in terms of their predictive power, with separate sections on computer predictions and simulation. Print version record. Toxicology. MEDICAL Pharmacology. bisacsh Toxicology. fast (OCoLC)fst01153364 Electronic books. Pfannkuch, Friedlieb. Suter-Dick, Laura. Mannhold, Raimund, 1948- Kubinyi, Hugo. Folkers, Gerd. Print version: Predictive Toxicology : From Vision to Reality, Volume 64. Hoboken : Wiley, ©2014 9783527336081 Methods and principles in medicinal chemistry. http://onlinelibrary.wiley.com/book/10.1002/9783527674183 Wiley Online Library ddc BK 207721 207721