04823cam a2200685 i 4500 ocn893202820 OCoLC 20171026104105.0 m o d cr ||||||||||| 141015s2015 enk ob 001 0 eng 2014040774 9781118695951 (ePub) 111869595X (ePub) 9781118695937 (Adobe PDF) 1118695933 (Adobe PDF) 1118633792 (cloth) 9781118633793 (cloth) 9781118633793 (cloth) 9781118695920 1118695925 EB00595602 Recorded Books CHBIS 010442355 CHVBK 334095786 DEBBG BV042792715 NZ1 15914117 DEBBG BV042991344 DEBBG BV043397206 (OCoLC)893202820 (OCoLC)904961961 (OCoLC)959872537 DLC eng rda pn DLC YDX DG1 N$T YDXCP OCLCF IDEBK RECBK IUL COO OCLCQ DEBBG eng rus pcc MAIN QP702.H8 MED 075000 bisacsh SCI 036000 bisacsh 612.015782 23 Khabarov, Vladimir N. Hyaluronic acid : preparation, properties, application in biology and medicine / V.N. Khabarov, P. Ya. Boykov and M.A. Selyanin ; translated from the Russian by scientific editor Dr. F. Polyak. [electronic resource] Chichester, West Sussex : John Wiley & Sons, Ltd., 2015. 1 online resource. text txt rdacontent computer c rdamedia online resource cr rdacarrier Includes bibliographical references and index. Hyaluronic acid is an essential part of connective, epithelialand neural tissues, and contributes to cell proliferation andmigration. It is used as a stimulating agent for collagen synthesisand is a common ingredient in skin-care products, a multi-billiondollar industry, as it is believed to be a key factor in fightingthe aging process. Hyaluronic Acid: Production, Properties, Application inBiology and Medicine consists of six chapters discussing thevarious issues of hyaluronic acid research. In Chapter 1, ahistorical analysis recounts the discovery and milestones of theresearch leading to the practical applications of hyaluronan. Chapter 2 is dedicated to biological role of the hyaluronic acid innature, in particular in the human body. The chapter starts fromthe phylogenesis of hyaluronic acid, then describes hyaluronanfunctions in human ontogenesis and especially the role whichhyaluronan plays in extracellular matrix of the different tissues. Chapter 3 describes the methods to manufacture and purifyhyaluronic acid, including the analytical means for assessingquality of the finished product. Chapter 4 discusses the structureand rheological properties of hyaluronic acid considering effectson conformation and biological properties related to molecularweight. In Chapter 5, the physical and chemical methods formodifying the structure of hyaluronan are discussed includingcross-linking using bi-functional reagents, solid-phasemodification and effects of the combined action of high pressuresand shift deformation. The final chapter focuses on the productsderived from hyaluronic acid, including therapeutics composed ofmodified hyaluronan conjugated to vitamins, amino acids andoligo-peptides. The biological roles and medical applications ofthis polysaccharide have been extensively studied and this bookprovides a wealth of scientific data demonstrating the criticalrole of hyaluronic acid and its promise as a multifacetedbio-macromolecule. Approaching hyaluronic acid from multiple angles, this booklinks relationships between its biological functions, structure andphysical'chemical properties. It will be an invaluableresource to researchers, both industrial and academic, involved inall aspects of hyaluronan-based technologies. Print version record and CIP data provided by publisher. Hyaluronic acid. Organic acids. MEDICAL Physiology. bisacsh SCIENCE Life Sciences Human Anatomy & Physiology. bisacsh Hyaluronic acid. fast (OCoLC)fst00964482 Organic acids. fast (OCoLC)fst01047633 Electronic books. Boykov, Petr Ya. Selyanin, Mikhail A. Print version: Khabarov, V.N. (Vladimir N.). Hyaluronic acid. Chichester, West Sussex : John Wiley & Sons, Inc., 2015 9781118633793 (DLC) 2014038400 http://onlinelibrary.wiley.com/book/10.1002/9781118695920 Wiley Online Library ddc BK 207710 207710