06344cam a2200805 i 4500 ocn888026267 OCoLC 20171026113229.0 m o d cr ||||||||||| 140818s2015 enk ob 001 0 eng 2014033073 9781118412671 (ePub) 1118412672 (ePub) 9781118412688 (Adobe PDF) 1118412680 (Adobe PDF) 9781118412640 1118412648 9781118274828 (cloth) DEBBG BV042793354 NZ1 15914919 AU@ 000055039224 (OCoLC)888026267 (OCoLC)904208857 (OCoLC)905866143 (OCoLC)961518517 (OCoLC)962728045 DLC eng rda pn DLC N$T DG1 OCLCF STF OCLCO EBLCP RECBK VLB OCLCQ OCLCO E7B DG1 K6U pcc MAIN RC848.C5 WI 725 HEA 039000 bisacsh MED 014000 bisacsh MED 022000 bisacsh MED 112000 bisacsh MED 045000 bisacsh 616.3/624 23 Cirrhosis (Lee) Cirrhosis : a practical guide to management / edited by Samuel S. Lee, Richard Moreau. [electronic resource] Chichester, West Sussex ; Hoboken, NJ : Wiley-Blackwell, 2015. 1 online resource. text txt rdacontent computer c rdamedia online resource cr rdacarrier Includes index. Includes bibliographical references and index. Cirrhosis: A Practical Guide to Management; Contents; List of contributors; Foreword; List of abbreviations; Part 1: Diagnosis and pathophysiology; 1. Clinical clues to the diagnosis of cirrhosis; Introduction; Clinical presentation; Patient history; Abdominal distension (ascites); Jaundice; Upper gastrointestinal bleeding; Hepatic encephalopathy; Etiologic history taking; Alcohol intake: how much is significant; History of other risk factors; Examination; General examination; Nutritional status; Cutaneous clues; Spider angioma; Palmar erythema; Dupuytren's contracture; Leukonychia. Muehrcke's nailsBier spots; Paper-money skin; Hypogonadism and gynecomastia; Parotidomegaly; Other manifestations; Abdominal examination; Abdominal veins; Cruveilhier-Baumgarten murmur; Examination of the liver; Examination of the spleen; Examination for ascites; Neurologic examination; References; 2. Diagnostic laboratory tests; Introduction; Tests that detects hepatic injury (Table 2.1); Serum aminotransferases; Serum biliary enzymes; Tests of hepatic metabolism (Table 2.1); Serum bilirubin; Serum ammonia; Indocyanine green and bromsulphalein tests. Tests of hepatic biosynthetic function (Table 2.2)Serum albumin; Prothrombin time and international normalized ratio; Individual serum coagulating factor levels; Factor VIII; Factors V and VII; Cell counts and other biochemistry (Table 2.2); Thrombocytopenia; Neutropenia; Anemia; Globulins; Hyponatremia; Accuracy of routine laboratory investigations (Table 2.3); Combination indices or models for detecting cirrhosis (Table 2.4); Specific tests for determining the etiology of liver cirrhosis; Tests for viral hepatitis; Tests for alcoholic liver disease; Tests for primary biliary cirrhosis. Tests for primary sclerosing cholangitisTests for hereditary hemochromatosis; Transferrin saturation; Plasma ferritin level; Tests for Wilson's disease; Serum ceruloplasmin; Serum copper; Urine copper excretion; Tests for alpha-1 antitrypsin deficiency; Conclusions; References; 3. Diagnostic imaging modalities; Ultrasonography-based approaches; Grayscale and Doppler US; Contrast-enhanced ultrasonography; Measurement of liver stiffness: transient elastography, acoustic radiation force impulse, supersonic shear-wave elastography, and real-time elastography; CT- and MRI-based approaches. Morphologic changesHemodynamic changes; MR elastography; Other imaging techniques; References; 4. Histology/pathology; Introduction; Cirrhosis: a pathologic spectrum; Fibrosis: extracellular accumulation of matrix components; Vascular changes; Parenchymal nodules: etiologic features; Cirrhosis: an evolving concept; Cirrhosis: a preneoplastic condition; Cirrhosis: a place for biopsy?; References; 5. Fibrosis and fibrogenesis; Introduction; Mechanism of liver fibrosis in hepatitis B and C; Diagnosis of liver fibrosis by imaging; Diagnosis of liver fibrosis by laboratory tests. Cirrhosis: a practical guide to management providesgastroenterologists and hepatologists with an up-to-date clinicalguide presenting the very best evidence-based practice in thediagnosis, treatment and management of liver cirrhosis and its manycomplications. Designed to offer practical guidance at alltimes, it provides doctors with an extremely useful tool in theclinical setting, with each chapter featuring diagnostic/managementalgorithms, key points and other pedagogic features. Divided into 2 parts, a diagnosis and pathophysiology section and amanagement of complications section, key topics. Print version record and CIP data provided by publisher. Liver Cirrhosis. Liver Cirrhosis diagnosis. Liver Cirrhosis therapy. Liver Diseases complications. Liver cirrhosis Diagnosis. Liver cirrhosis Therapy. Liver diseases Complications. HEALTH & FITNESS Diseases General. bisacsh MEDICAL Clinical Medicine. bisacsh MEDICAL Diseases. bisacsh MEDICAL Evidence-Based Medicine. bisacsh MEDICAL Internal Medicine. bisacsh Liver Cirrhosis. fast (OCoLC)fst01000632 Electronic books. Lee, Samuel S., 1954- editor. Moreau, Richard, 1951- editor. Print version: Chichester, West Sussex ; Hoboken, NJ : John Wiley & Sons Inc., 2015 9781118274828 (DLC) 2014032682 http://onlinelibrary.wiley.com/book/10.1002/9781118412640 Wiley Online Library ddc BK 207631 207631