06812cam a2200733 i 4500 ocn879851949 OCoLC 20171030102614.0 m o d cr ||||||||||| 140514s2014 nju ob 001 0 eng 2014019036 9781118876022 (epub) 1118876024 (epub) 9781118876091 (pdf) 1118876091 (pdf) 9781118876015 1118876016 1118466616 (hardback) 9781118466612 (hardback) 9781118466612 (hardback) AU@ 000052883823 CHBIS 010441709 CHVBK 334089182 DEBSZ 431778434 DEBBG BV043396768 (OCoLC)879851949 (OCoLC)893685368 (OCoLC)933561027 (OCoLC)959871329 (OCoLC)961611452 (OCoLC)962662548 DLC eng rda pn DLC YDX OCLCF EBLCP N$T YDXCP DG1 E7B DEBSZ COO MEU OCLCQ CSJ OCLCQ DEBBG OCLCQ pcc MAIN QD75.22 SCI 013010 bisacsh 543/.19 23 SCI013040 SCI045000 SCI013010 bisacsh Natural products analysis : instrumentation, methods, and applications / edited by Vladimir Havlicek, Laboratory of Molecular Structure Cjaracterization, Academy of Sciences of the Czech Republick, Prague, Czech Republic, Jaroslav Spizek, Laboratory of Physiology and Genetics of Actinomycetes, Institute of Microbiology, Academy of Sciences of the Czech Republic, Prague, Czech Republic. [electronic resource] Hoboken, New Jersey : Wiley, 2014. 1 online resource. text txt rdacontent computer c rdamedia online resource cr rdacarrier Includes bibliographical references and index. Natural Products Analysis: Instrumentation, Methods,and Applications; Copyright; Contents; Preface; Contributors; Chapter 1 Natural Products Analysis: Instrumentation, Methods, and Applications; 1.1 Book Motivation; 1.2 The Broad Field of Natural Products; 1.3 Discovery Phases; 1.4 Absolute Structure; 1.5 Mass Spectral Applications in Concert; 1.6 Complex Structures and Complex Mixtures; References; Chapter 2 The Need for New Antifungal and Antimalarial Compounds; 2.1 Introduction; 2.2 Fungal Infections; 2.2.1 Fungal Diseases; 2.2.2 Antifungal Therapy; 2.2.3 Fluoropyrimidines; 2.2.4 Azoles 2.2.5 Echinocandins2.2.6 Other Peptides; 2.2.7 Polyenes; 2.2.8 Miscellaneous Antifungals; 2.3 Malaria; 2.3.1 The Disease; 2.3.2 Quinine; 2.3.3 Artemisinin; 2.3.4 Tetracyclines; 2.3.5 Clindamycin; 2.3.6 Combinations of Drugs; 2.4 Conclusions; References; Chapter 3 Emerging Instrumental Methods for Antimicrobial Resistance and Virulence Testing; 3.1 Introduction; 3.2 Mass Spectrometry; 3.3 Nucleic Acid Amplification and Sequencing; 3.4 Perspective; Acknowledgment; References; Chapter 4 Plant and Marine Sources: Biological Activity of Natural Products and Therapeutic Use; 4.1 Introduction 4.2 Significance of Plant Sources4.2.1 Methods Used in Chemistry of Plant-Derived Products; 4.2.2 Chemistry and the Modes of Action of Plant Metabolites; 4.3 Impact of Marine Natural Products; 4.3.1 Marine Chemical Biology; 4.4 Natural Products and Diseases; 4.4.1 Endocrine System-Diabetes; 4.4.2 Cardiovascular Ailments; 4.4.3 Antiplatelet and Antisclerotic Drugs; 4.4.4 Diseases Correlated with Problems of the Central Nervous System (CNS); 4.4.5 Plants Used Against the Respiratory Disorders; 4.4.6 Infectious Diseases and the Use of Plant- or Marine-Derived Drugs 4.4.7 Anticancer Drugs from Plants and Marine Sources4.5 Conclusions; References; Chapter 5 Emerging Trends for Stimulating the Discovery of Natural Products; 5.1 Mass Spectrometry-Based Metabolomics; 5.2 Metagenomics and Symbiosis; 5.3 Bioinformatic Annotation of Biosynthetic Pathways and Structure Prediction; 5.4 New Tools For Absolute Configuration Determination; References; Chapter 6 Advances and Challenges in Optical Molecular Spectroscopy Including Surface Plasmon Resonance-Based Methods for Bioanalysis; 6.1 Introduction to Principles and Analytical Aspects of Optical Spectroscopy 6.1.1 Description of Electromagnetic Radiation and Its Propagation6.1.2 Light Absorption and the Beer-Lambert-Bouguer Law; 6.1.3 Deviations from the Beer-Lambert-Bouguer Law; 6.1.4 Calibration Methods in Optical Spectroscopy; 6.1.5 Multivariate Quantitative Models; 6.1.6 Multivariate Classification Models; 6.2 Molecular Spectroscopy and Its Instrumentation; 6.2.1 Types of Molecular Optical Spectroscopic Methods; 6.2.2 General Types of Instrumentation; 6.2.3 Electronic States and Electronic Spectroscopy; 6.2.4 Vibrational States and Methods of Vibrational Spectroscopy "This book highlights analytical chemistry instrumentation and practices applied to the analysis of natural products and their complex mixtures, describing techniques for isolating and characterizing natural products. Applies analytical techniques to natural products research - an area of critical importance to drug discovery Offers a one-stop shop for most analytical methods: X-ray diffraction, NMR analysis, mass spectrometry, and chemical genetics Includes coverage of natural products basics and highlights antibacterial research, particularly important as efforts to combat drug resistance gain prominence Covers instrumental techniques with enough detail for both current practitioners and beginning researchers"-- Provided by publisher. "This book highlights analytical chemistry instrumentation and practices applied to the analysis of natural products and their complex mixtures, describing techniques for isolating and characterizing natural products"-- Provided by publisher. Text in English. Print version record and CIP data provided by publisher. Natural products Analysis. Chemistry, Analytic. SCIENCE Chemistry Organic. bisacsh SCIENCE Life Sciences Biology Microbiology. bisacsh SCIENCE Chemistry Analytic. bisacsh Chemistry, Analytic. fast (OCoLC)fst00853459 Natural products Analysis. fast (OCoLC)fst01034391 Electronic books. Havlíček, Vladimír, editor. Spižek, Jaroslav, editor. Print version: Natural products analysis. Hoboken, New Jersey : Wiley, 2014 9781118466612 (DLC) 2014008371 http://onlinelibrary.wiley.com/book/10.1002/9781118876015 Wiley Online Library ddc BK 207442 207442