Drug transporters : molecular characterization and role in drug disposition - You, Guofeng; Morris, Marilyn Emily (Hoboken, New Jersey : John Wiley & Sons, Inc., 2014)
Overview of drug transporter families -- Organic Cation and Zwitterion transporters OCT, OCTN -- Organic anion transporters OAT -- Organic anion transporting polypeptides OATP -- Mammalian peptide transporters PEPT -- The monocarboxylate transporters MCT -- The nucleoside transporters CNT, ENT -- Bile acid transporters -- Multidrug resistance protein P-glycoprotein -- Multidrug resistance-associated proteins MRP -- Breast cancer resistance protein BCRP -- Multidrug and toxin extrusion proteins MATE -- Drug transport in the liver -- Drug transport in the brain -- Drug transport in the kidney -- Drug transport in the intestine -- Drug transport in the placenta -- Experimental approaches to studying drug transport -- Transporters in drug discovery in silico approaches -- Polymorphisms of drug transporters and clinical relevance -- Diet/nutrient interactions with drug transporters -- Clinical relevance drug-drug interactions, pharmacokinetics, pharmacodynamics and toxicity -- Regulatory science perspectives on transporter studies in drug development.
Includes bibliographical references and index.
Description based on print version record and CIP data provided by publisher.
Keywords: Carrier proteins; Drug carriers (Pharmacy); SCIENCE -- Life Sciences -- Anatomy & Physiology; Carrier proteins; Drug carriers (Pharmacy); Biological Transport -- physiology; Membrane Transport Proteins -- physiology; Pharmacokinetics; Pharmakokinetik; Arzneimittel; Chemische Synthese; Arzneimittelwechselwirkung; Electronic books; Electronic books