05911cam a2200757 i 4500 ocn869847755 OCoLC 20171031102809.0 m o d cr ||||||||||| 140127s2014 iau ob 001 0 eng 2014003283 9781118847015 (ePub) 1118847016 (ePub) 9781118846940 (Adobe PDF) 111884694X (Adobe PDF) 9781118125656 (hardback) 9781118847237 (electronic bk.) 1118847237 (electronic bk.) 1118125657 9781118125656 NZ1 15581391 CHVBK 325939896 CHBIS 010259650 NZ1 15906859 GBVCP 821064541 AU@ 000058366570 DEBBG BV043396525 (OCoLC)869847755 (OCoLC)927509063 DLC eng rda DLC YDX N$T YDXCP E7B CUS DG1 OCLCF CDX RECBK COO EBLCP DEBBG pcc MAIN QP551 SCI 056000 bisacsh 571.6/58 23 SCI017000 bisacsh Ribosome-inactivating proteins : biology and applications / edited by Fiorenzo Stirpe, Dipartimento di Medicina Specialistica, Diagnostica e Sperimentale, Alma Mater Studiorum Università di Bologna, Bologna, Italy, Douglas A. Lappi, Advanced Targeting Systems, Inc., San Diego, California, USA. [electronic resource] Ames, Iowa : Wiley, 2014. 1 online resource. text rdacontent computer rdamedia online resource rdacarrier Includes bibliographical references and index. ""Title page""; ""Copyright page""; ""Contributors""; ""Preface""; ""1 Introduction and History""; ""Introduction""; ""Identification and Distribution in Nature""; ""Mechanism of Action""; ""Effects on Cells and Animals""; ""Role in Nature""; ""Practical Applications""; ""Bioweapons""; ""Future Challenges""; ""References""; ""2 Occurrence and Taxonomical Distribution of Ribosome-inactivating Proteins Belonging to the Ricin/Shiga Toxin Superfamily""; ""Introduction""; ""How to Investigate the Distribution of Proteins with an N-glycosidase Domain?""; ""Conclusions""; ""Acknowledgments"" ""Introduction""""Family Sambuceae""; ""Type 2 RIPs from Other families""; ""Uses of nontoxic type 2 RIPs""; ""Concluding remarks""; ""Acknowledgment""; ""References""; ""6 The Intracellular Journey of Type 2 Ribosome-inactivating Proteins""; ""Introduction""; ""Cell Surface Events""; ""Endosome to TGN Sorting""; ""From the Golgi to the ER""; ""Reductive Separation and Destabilization of the Holotoxin Subunits""; ""Dislocation Across the ER Membrane""; ""Cytosolic Post-dislocation Events that Restore Catalytic Activity""; ""Concluding Remarks""; ""Acknowledgements""; ""References"" ""7 Shiga Toxins""""Introduction""; ""Purification of Shiga Toxins""; ""Structure and Mechanism of Action of Shiga Toxins""; ""Role of Shiga Toxins in the Pathogenesis of HUS""; ""The 2011 German STEC Outbreak""; ""References""; ""8 The Structure and Action of Ribosome-inactivating Proteins""; ""Introduction""; ""Acknowledgments""; ""References""; ""9 Updated Model of the Molecular Evolution of RIP Genes""; ""Introduction""; ""Important Issues to be Considered in View of the Evolution of RIP Genes"" ""Dissecting RIP Genes and RIP Gene Families by in silico Analysis of Genome and Transcriptome Data""""New Insights in the Overall Phylogeny of Plant RIPs""; ""An Updated Model of the Molecular Evolution of the Plant RIP Gene Family""; ""What is the Evolutionary Link Between Plant and Non-Plant RIPs?""; ""Conclusions""; ""References""; ""10 Enzymology of the Ribosome-inactivating Proteins""; ""Introduction""; ""Ricin as RNA N-glycosidase""; ""Role of SRL in Ribosomes""; ""Ribosomal RNA Apurinic Site-specific Lyase â€" Intrinsic Stability of the Ribosomes""; ""Action of RIPs on DNA"" "This important reference provides up-to-date information on all aspects of ribosome-inactivating proteins (RIPs). Including a list of all known RIPs, their distribution in nature, structure, genetics and chemical and immunological properties, this reference covers mechanisms of action, including the enzymatic activity on various polynucleotide substrates; the interaction with, and entry into cells; the toxicity to animals, including the pathology of poisoning; and the immunomodulatory and allergenic activity. The book further emphasizes the use of immunotoxins and other conjugates in clinical trials for the therapy of cancer and intractable pain"-- Provided by publisher. "Ribosome-inactivating Proteins is a reference book which will provide up-to-date information on all aspects of ribosome-inactivating proteins (RIPs)"-- Provided by publisher. Description based on print version record and CIP data provided by publisher. Proteins Synthesis. Ribosomes Structure. SCIENCE / Life Sciences / Cytology. bisacsh Protein Biosynthesis. Ribosomes. Proteins Synthesis. fast (OCoLC)fst01079764 Ribosomes Structure. fast (OCoLC)fst01097321 SCIENCE Life Sciences Cytology. Electronic books. Electronic books. Stirpe, Fiorenzo, editor of compilation. Lappi, Douglas A., editor of compilation. Print version: Ribosome-inactivating proteins Ames, Iowa : John Wiley & Sons Inc., 2014 9781118125656 (DLC) 2014002677 http://onlinelibrary.wiley.com/book/10.1002/9781118847237 Wiley Online Library ddc BK 207258 207258