06110cam a2200877 i 4500 ocn867001327 OCoLC 20171031134430.0 m o d cr ||||||||||| 131230s2014 nju ob 001 0 eng 2013051091 016683246 Uk 9781118501658 (epub) 1118501659 (epub) 9781118501641 (pdf) 1118501640 (pdf) 9781118501627 (hardback) 9781118501665 1118501667 1306473551 9781306473552 1118501624 9781118501627 NZ1 15497379 CHVBK 330903020 CHDSB 006350722 NZ1 15906654 NZ1 16092123 DEBBG BV042796336 (OCoLC)867001327 (OCoLC)871633036 (OCoLC)927508391 (OCoLC)940437378 (OCoLC)961547303 (OCoLC)962573345 578606 MIL DLC eng rda DLC YDX EBLCP DG1 E7B N$T CUS IDEBK UKMGB YDXCP OHI CDX RECBK NLGGC OCLCO CHVBK COO DEBBG OCLCF pcc MAIN RC268.4 QZ 266 HEA 039000 bisacsh MED 014000 bisacsh MED 022000 bisacsh MED 112000 bisacsh MED 045000 bisacsh 616.99/4042 23 Cancer gene therapy by viral and non-viral vectors / edited by Malcolm K. Brenner, Mien-Chie Hung. [electronic resource] Hoboken, New Jersey : Wiley Blackwell, [2014] 1 online resource. text rdacontent computer rdamedia online resource rdacarrier Translational oncology ; 4 Machine generated contents note: ContributorsSeries ForewordPreface Part I: Delivery Systems 1. Translational Cancer Research: Gene Therapy by Viral and Non-viral Vectors Vincenzo Cerullo, Kilian Guse, Markus Vaha-Koskela and Akseli Hemminki 2. Retroviruses for Cancer Therapy Jiehua Zhou, Yue Ding, John Burnett and John Rossi 3. DNA Plasmids for Non-viral Gene Therapy of Cancer Amer N. Najjar, Judy S.E. Moyes and Laurence J.N. Cooper 4. Cancer Therapy with RNAi delivered by Nonviral Membrane/Core Nanoparticles Andrew B. Satterlee and Leaf Huang Part II: Targeted Expression 5. Cancer Gene Therapy by Tissue-specific and Cancer-targeting Promoters Jennifer L. Hsu, Longfei Huo, Chia-Wei Li, Yi-Hsin Hsu, Yan Wang and Mien-Chie Hung 6. MicroRNAs as Drugs and Drug Targets in Cancer Hui Ling and George A. Calin Part III: Principles of Clinical Trials in Gene Therapy 7. Regulatory Issues for Manufacturers of Viral Vectors and Vector-Transduced Cells for Phase I/II Trials Adrian P. Gee and Zhuyong Mei 8. U.S. Regulations Governing Clinical Trials in Gene Therapy Bambi Grilley 9. Remaining Obstacles to the Success of Cancer Gene Therapy Malcolm K. BrennerIndex. Includes bibliographical references and index. "Translational medicine has opened the gateway to the era of personalized medicine. No longer a one-size-fits-all approach, the treatment of cancer is now based on an understanding of underlying biologic mechanisms and is increasingly being tailored to the molecular specificity of a tumor. Gene therapy in cancer has faced many technical barriers in the past but has recently shown significant progress that could allow stem cell and gene transfer therapies to make a major contribution to cancer therapy. The time appears ripe for a good, authoritative, book-length review of the state-of-the-art in this field. Gene Therapy by Viral and Non-viral Vectors provides a comprehensive overview of the pertinent molecular discoveries in the cancer field and explains the clinical ramifications and utility of these on gene-based cancer therapies. Designed as a volume in the book series Translational Oncology, edited by Robert Bast, Maurie Markman, and Ernest Hawk, this new book deals with the practice of gene therapy with reference to vectors for gene expression and gene transfer as well as viral therapy, and it will very nicely complement other books in the series, especially the volumes on immunotherapy and cell therapy. The content of the book also covers the history and current and future applications of gene transfer in cancer. This new volume provides expert insight on the current progress of viral and nonviral gene therapy with regard to delivery system, vector design, potential therapeutic genes, and principles and regulations for cancer gene therapy. It offers important and immediately applicable information to investigators, clinician-researchers, and medcial and graduate students with interest in this vital area of research"--Provided by publisher. Description based on print version record and CIP data provided by publisher. Cancer Gene therapy. Genetic vectors Therapeutic use. HEALTH & FITNESS Diseases General. bisacsh MEDICAL Clinical Medicine. bisacsh MEDICAL Diseases. bisacsh MEDICAL Evidence-Based Medicine. bisacsh MEDICAL Internal Medicine. bisacsh Neoplasms therapy. Genetic Therapy. Genetic Vectors therapeutic use. Oncolytic Virotherapy. Genetic Therapy. Gene therapy. fast (OCoLC)fst00939638 Electronic books. Electronic books. Brenner, Malcolm K., 1951- editor of compilation. Hung, Mien-chie, editor of compilation. Print version: Cancer gene therapy by viral and non-viral vectors Hoboken, New Jersey : John Wiley & Sons, [2014] 9781118501627 (DLC) 2013049552 Translational oncology (Series) ; 4. http://onlinelibrary.wiley.com/book/10.1002/9781118501665 Wiley Online Library ddc BK 207179 207179