05271cam a2200709Ia 4500 ocn864744144 OCoLC 20171105083452.0 m o d cr cnu---unuuu 131206s2014 gw ob 001 0 eng d 9783527677283 (electronic bk.) 3527677283 (electronic bk.) 9783527677252 (electronic bk.) 3527677259 (electronic bk.) 1306168902 (electronic bk.) 9781306168908 (electronic bk.) 9783527333943 3527333940 9783527677269 (Mobi) 3527677267 (Mobi) 9783527677276 (ePub) 3527677275 (ePub) DEBBG BV043396386 DEBSZ 43157054X NZ1 15495746 NZ1 15905579 (OCoLC)864744144 (OCoLC)870511683 (OCoLC)961643563 (OCoLC)962637366 548141 MIL IDEBK eng pn IDEBK EBLCP DG1 N$T YDXCP OCLCF OCLCQ DEBSZ COO DEBBG OCLCQ CDX MAIN RS403 RM111 .L384 2013 QV 744 MED 071000 bisacsh 615.1/9 23 Medicinal chemistry approaches to personalized medicine / edited by Karen Lackey and Bruce D. Roth. [electronic resource] Weinheim : Wiley-VCH, 2014. 1 online resource. text txt rdacontent computer c rdamedia online resource cr rdacarrier Medicinal chemistry ; Volume 59 Includes bibliographical references and index. Methods and Principles in Medicinal Chemistry; Title Page; Copyright; List of Contributors; Foreword; Preface; A Personal Foreword; Acronyms; Chapter 1: Medicinal Chemistry Approaches to Creating Targeted Medicines; 1.1 Introduction; 1.2 Role of Medicinal Chemistry in Drug Discovery; 1.3 Evolution of Molecular Design for Subsets of Patients; 1.4 Combinations for Effective Therapies; 1.5 Biomarkers in Targeting Patients; 1.6 Emerging Field of Epigenetics; 1.7 Systems Chemical Biology; 1.8 Theranostics and Designing Drug Delivery Systems 1.9 Rapid Progress in Further Personalizing Medicine ExpectedReferences; Chapter 2: Discovery of Predictive Biomarkers for Anticancer Drugs; 2.1 Introduction; 2.2 "Oncogene Addiction" as a Paradigm for Clinical Implementation of Predictive Biomarkers; 2.3 Cancer Cell Lines as a Model System for Discovery of Predictive Biomarkers; 2.4 Modeling Drug Resistance to Discover Predictive Biomarkers; 2.5 Discovery of Predictive Biomarkers in the Context of Treatment Combinations; 2.6 Discovery of Predictive Biomarkers for Antiangiogenic Agents; 2.7 Gene Expression Signatures as Predictive Biomarkers 2.8 Current Challenges in Discovering Predictive Biomarkers2.9 Future Perspective; References; Chapter 3: Crizotinib; 3.1 Introduction; 3.2 Discovery of Crizotinib ( PF -02341066) [40]; 3.3 Kinase Selectivity of Crizotinib; 3.4 Pharmacology of Crizotinib [45,46]; 3.5 Human Clinical Efficacies of Crizotinib; 3.6 Summary; References; Chapter 4: Discovery and Development of Vemurafenib: First-in-Class Inhibitor of Mutant BRAF for the Treatment of Cancer; 4.1 Background; 4.2 Discovery and Development of Vemurafenib (PLX4032); 4.3 Pharmacology; 4.4 Clinical Efficacy and Safety 4.5 Companion Diagnostic (cobas 4800) Development4.6 Synthesis; 4.7 Summary; References; Chapter 5: Targeting Basal-Cell Carcinoma: Discovery and Development of Vismodegib ( GDC -0449), a First-in-Class Inhibitor of the Hedgehog Pathway; 5.1 Introduction; 5.2 Hedgehog and Basal-Cell Carcinoma; 5.3 Cyclopamine as an SMO Antagonist; 5.4 Small-Molecule Inhibitors of SMO; 5.5 Preclinical Characterization of Vismodegib; 5.6 Vismodegib Clinical Experience in Phase I; References; Chapter 6: G-Quadruplexes as Therapeutic Targets in Cancer; 6.1 Introduction; 6.2 Quadruplex Fundamentals 6.3 Genomic Quadruplexes6.4 Quadruplexes in Human Telomeres; 6.5 Quadruplexes as Anticancer Targets -- Evidence from In Vivo Studies; 6.6 Native Quadruplex Structures; 6.7 Quadruplex-Small-Molecule Structures; 6.8 Developing Superior Quadruplex-Binding Ligands; 6.9 Conclusions; References; Chapter 7: Identifying Actionable Targets in Cancer Patients; 7.1 Introduction and Background; 7.2 Overview of Genomic Sequencing and Its Impact on the Identification of Actionable Mutations; 7.3 Actionable Targets by Clinical Molecular Profiling: the OICR / PMH Experience Print version record. Pharmaceutical chemistry. MEDICAL Pharmacology. bisacsh Pharmaceutical chemistry. fast (OCoLC)fst01060115 Electronic books. Electronic books. Lackey, Karen. Roth, Bruce D. Print version: Medicinal chemistry approaches to personalized medicine. Weinheim : Wiley-VCH, 2014 9783527677252 Medicinal chemistry ; Volume 59. http://onlinelibrary.wiley.com/book/10.1002/9783527677252 Wiley Online Library ddc BK 207126 207126