04759cam a2200745 i 4500 ocn862929262 OCoLC 20171105091344.0 m o d cr ||||||||||| 131108s2014 iau ob 001 0 eng 2013045062 9781118794609 (ePub) 1118794605 (ePub) 9781118794678 (Adobe PDF) 1118794672 (Adobe PDF) 9781118794623 (electronic bk.) 1118794621 (electronic bk.) 9781118298060 (hardback) CHBIS 010259552 CHDSB 006249965 CHVBK 315195924 CHVBK 325942382 GBVCP 813894433 NLGGC 373213832 NZ1 15568463 NZ1 15906731 DEBBG BV043396334 (OCoLC)862929262 DLC eng rda pn DLC YDX N$T DG1 CUS YDXCP CHVBK OCLCF MMU NLGGC E7B OCLCQ OCLCO DEBBG EBLCP OCLCQ OCLCO OCLCA MERER OCLCO pcc MAIN QR186 QW 800 SCI 008000 bisacsh 574.29 23 Natural products (2014) Natural products : discourse, diversity and design / [edited by] Anne Osbourn, Rebecca J. Goss. [electronic resource] Ames, Iowa ; Chichester, West Sussex, UK : John Wiley & Sons, 2014. 1 online resource. text txt rdacontent computer c rdamedia online resource cr rdacarrier Includes index. Includes bibliographical references and index. Natural products in the natural world -- Role and reason -- Self-protection: avoiding autotoxicity -- Fishing and pharming -- From genes to molecules -- Reading the genome -- Biosynthesis and heterologous expression -- Regulation: waking sleeping pathways -- Evolving enzymes, evolving pathways: synthetic biology -- Chemical diversification -- Evolving pathways -- Synthetic biology -- Screening for bioactivity -- Image-based screening approaches to natural products discovery -- Making sense of structures by utilizing Mother Nature's chemical libraries as leads to potential drugs -- Is there an ideal d1atabase for natural products research? -- To application -- Case studies. "Natural Products: Discourse, Diversity and Design provides an informative and accessible overview of discoveries in the area of natural products in the genomic era, bringing together advances across the kingdoms. As genomics data makes it increasingly clear that the genomes of microbes and plants contain far more genes for natural product synthesis than had been predicted from the numbers of previously identified metabolites, the potential of these organisms to synthesize diverse natural products is likely to be far greater than previously envisaged. Natural Products addresses not only the philosophical questions of the natural role of these metabolites, but also the evolution of single and multiple pathways, and how these pathways and products may be harnessed to aid discovery of new bioactives and modes of action. Edited by recognized leaders in the fields of plant and microbial biology, bioorganic chemistry and natural products chemistry, and with contributions from researchers at top labs around the world, Natural Products is unprecedented in its combination of disciplines and the breadth of its coverage. Natural Produces: Discourse, Diversity and Design will appeal to advanced students and experienced researchers, from academia to industry, in diverse areas including ecology, industrial biotechnology, drug discovery, medicinal chemistry, agronomy, crop improvement, and natural product chemistry"--Provided by publisher. Print version record and CIP data provided by publisher. Natural products. Biological products. SCIENCE Life Sciences Biology. bisacsh Biological products. fast (OCoLC)fst00832292 Natural products. fast (OCoLC)fst01034390 Biological Factors. Microbiological Phenomena genetics. Biochemical Phenomena genetics. Drug Discovery. Synthetic Biology methods. Electronic books. Osbourn, Anne E., editor. Goss, Rebecca J., editor. Print version: Ames, Iowa : John Wiley & Sons, 2014 9781118298060 (DLC) 2013042697 http://onlinelibrary.wiley.com/book/10.1002/9781118794623 Wiley Online Library ddc BK 207084 207084