05306cam a2200841 i 4500 ocn861789137 OCoLC 20171106082202.0 m o d cr ||||||||||| 131029s2014 njua ob 000 0 eng 2013043100 9781118836323 (pdf) 1118836324 (pdf) 9781118836309 (epub) 1118836308 (epub) 9781118836538 (mobi) 1118836537 (mobi) 9781118836507 (electronic bk.) 1118836502 (electronic bk.) 9780470566688 (cloth) 047056668X 9780470566688 AU@ 000052169909 NZ1 15497427 NZ1 15906674 CHVBK 334094607 CHBIS 010442024 DEBSZ 431651698 NZ1 16092114 DEBBG BV042793875 DEBBG BV042989477 DEBBG BV043396304 (OCoLC)861789137 (OCoLC)905856765 DLC eng rda pn DLC YDX EBLCP IDEBK DG1 N$T E7B CUS CDX OCLCF VRC YDXCP RECBK NLGGC OCLCQ OCLCO COO DEBSZ DEBBG pcc MAIN QP370 QU 136 MED 075000 bisacsh SCI 036000 bisacsh 612.8/2 23 Cyclic-nucleotide phosphodiesterases in the central nervous system : from biology to drug discovery / edited by Nicholas J. Brandon, Anthony R. West. [electronic resource] Hoboken, New Jersey : John Wiley & Sons, Inc., [2014] 1 online resource (xi, 386 pages) : illustrations (some color). text txt rdacontent computer c rdamedia online resource cr rdacarrier Wiley series in drug discovery and development Includes bibliographical references. Phosphodiesterases and cyclic nucleotide signaling in the CNS / Marco Conti and Wito Richter -- Putting together the pieces of phosphodiesterase distribution patterns in the brain : a jigsaw puzzle of cyclic nucleotide regulation / Michy P. Kelly -- Compartmentalization and regulation of cyclic nucleotide signalling in the CNS / Manuela Zaccolo and Alessandra Stangherlin -- Pharmacological manipulation of cyclic nucleotide phosphodiesterase signaling for the treatment of neurological and psychiatric disorders in the brain / Frank S. Menniti, Niels Plath, Christopher J. Schmidt, and Niels Svenstrup -- Recent results in phosphodiesterase inhibitor development and CNS applications / David P. Rotella -- Crystal structures of phosphodiesterases and implication on discovery of inhibitors / Hengming Ke, Huanchen Wang, Mengchun Ye, and Yingchun Huang -- Inhibition of cyclic nucleotide phosphodiesterases to regulate memory / Han-Ting Zhang, Ying Xu, James O'Donnell -- Emerging role for PDE4 in neuropsychiatric disorders : translating advances from genetic studies into relevant therapeutic strategies / Sandra P. Zoubovsky, Nicholas J. Brandon P, and Akira Sawa -- Beyond erectile dysfunction : understanding PDE5 activity in the central nervous system / Eva P.P. Bollen, Kris Rutten, Olga A.H. Reneerkens, Harry M.W Steinbusch, and Jos Prickaerts -- Molecular and cellular understanding of PDE10A : a dual-substrate phosphodiesterase with therapeutic potential to modulate basal ganglia function / Erik I. Charych and Nicholas J. Brandon -- Role of cyclic nucleotide signaling and phosphodiesterase activation in the modulation of electrophysiological activity of central neurons / Sarah Threlfell and Anthony R. West -- The role of phosphodiesterases in dopamine systems governing motivated behavior / Gretchen L. Snyder, Akinori Nishi, and Joseph P. Hendrick -- Inhibition of phosphodiesterases as a strategy for treatment of spinal cord injury / Elena Nikulina and Marie T. Filbin. Print version record and CIP data provided by publisher. Cyclic nucleotide phosphodiesterases. Central nervous system Physiology. Nucleotides, Cyclic. 3',5'-Cyclic-AMP Phosphodiesterases metabolism. 3',5'-Cyclic-AMP Phosphodiesterases therapeutic use. Central Nervous System physiology. Central Nervous System Diseases drug therapy. Drug Discovery. MEDICAL Physiology. bisacsh SCIENCE Life Sciences Human Anatomy & Physiology. bisacsh Central nervous system. fast (OCoLC)fst00850724 Cyclic nucleotide phosphodiesterases. fast (OCoLC)fst00885846 Electronic books. Electronic books. Brandon, Nicholas J., editor. West, Anthony R., 1970- editor. Print version: Cyclic-nucleotide phosphodiesterases in the central nervous system. Hoboken, New Jersey : John Wiley & Sons, Inc., [2014] 9780470566688 (DLC) 2013042742 (OCoLC)861755359 Wiley series in drug discovery and development. http://onlinelibrary.wiley.com/book/10.1002/9781118836507 Wiley Online Library ddc BK 207057 207057