06204cam a2200889 i 4500 ocn859253561 OCoLC 20171106082828.0 m o d cr ||||||||||| 130930s2014 njua ob 001 0 eng 2013039801 9781118826553 (ePub) 1118826558 (ePub) 9781118826676 (Adobe PDF) 1118826671 (Adobe PDF) 9781118826621 1118826620 9781306533058 1306533058 9781118160305 (cloth) 1118160304 CHBIS 010259527 CHVBK 325942951 NZ1 15624997 NZ1 16094369 DEBBG BV043396251 (OCoLC)859253561 (OCoLC)905855117 (OCoLC)908035488 (OCoLC)929527297 (OCoLC)961593577 (OCoLC)962633960 DLC eng rda pn DLC YDX N$T EBLCP YDXCP IDEBK DG1 E7B CUI CDX COO OCLCF RECBK OCLCQ OCLCO OCLCQ DEBBG pcc MAIN RC268.5 QZ 202 HEA 039000 bisacsh MED 014000 bisacsh MED 022000 bisacsh MED 112000 bisacsh MED 045000 bisacsh 616.99/401 23 Cancer and inflammation mechanisms : chemical, biological, and clinical aspects / edited by Dr. Yusuke Hiraku, Dr. Shosuke Kawanishi, Dr. Hiroshi Ohshima. [electronic resource] Hoboken, New Jersey : Wiley, [2014] 1 online resource (xvi, 383 pages) : illustrations text txt rdacontent computer c rdamedia online resource cr rdacarrier Includes index. Includes bibliographical references and index. Titlepage; Copyright; Contents; CONTRIBUTORS; PREFACE; CHAPTER 1 INFECTION, INFLAMMATION, AND CANCER: OVERVIEW; INFECTION, INFLAMMATION, AND CANCER: POSSIBLE MECHANISMS; PRODUCTION OF INFLAMMATORY MEDIATORS AND REACTIVE OXIDANTS; DNA AND PROTEIN DAMAGE BY ROSs AND RNSs; INFLAMMATION, EPIGENETIC MODIFICATION, AND microRNA; CONCLUDING REMARKS; REFERENCES; CHAPTER 2 STEM CELL THEORY AND INFLAMMATION-RELATED CANCER; CHRONIC INFLAMMATION AND CANCER; CANCER STEM CELLS; CARCINOGENIC FACTORS ARISING FROM CHRONIC INFLAMMATION; CHRONIC INFLAMMATION AND NORMAL STEM CELL FUNCTION Inflammation and the development and regulation of cancer stem cellsconcluding remarks; references; chapter 3 epithelial-mesenchymal transition: a link between cancer and inflammation; emt: a link between cancer and inflammation; q1: how are emt-permissive, inflammatory tumor microenvironments created?; q2: which emt-promoting signals are provided by inflammatory tumor microenvironments?; q3: how do emt-promoting signals influence the migratory behavior of tumor cells?; conclusions and future prospects; references; chapter 4 role of nitrative dna damage in inflammation- related carcinogenesis Dna damage during chronic inflammationliver fluke-induced cholangiocarcinoma; hpv-induced cervical cancer; ebv-induced nasopharyngeal carcinoma; dna damage induced by asbestos exposure; dna damage induced by carbon nanotube; soft tissue tumors and prognosis of tumor patients; conclusions and future prospects; references; chapter 5 lipid peroxidation-derived dna adducts and the role in inflammation-related carcinogenesis; lpo-derived reactive products contribute to dna damage; results and discussion; conclusions and future prospects; references CHAPTER 6 LEVEL OF INFLAMMATION-RELATED DNA ADDUCTS IN HUMAN TISSUESLEVEL OF 4-ONE- AND 4-OHE-DERIVED DNA ADDUCTS IN HUMAN TISSUES; BIOLOGICAL PROPERTIES OF 4-ONE- AND 4-OHE-DERIVED DNA ADDUCTS; INFLAMMATION AND FORMATION OF 4-ONE; CONCLUDING REMARKS; REFERENCES; CHAPTER 7 TOLL-LIKE RECEPTORS: ROLE IN INFLAMMATION AND CANCER; TLRs AND THEIR LIGANDS; TLR SIGNALING; MYD88-DEPENDENT SIGNALING PATHWAYS; TRIF-DEPENDENT SIGNALING PATHWAYS; INNATE IMMUNE CELLS IN CANCER TISSUES; TLRs AND TUMOR MICROENVIRONMENT; TOLL-LIKE RECEPTORS IN CANCER AND TUMOR THERAPY; ANTITUMOR ACTIVITY OF TLR LIGANDS ROLES OF TLRs IN CANCER PROGRESSIONCURRENT AND FUTURE DEVELOPMENTS; REFERENCES; CHAPTER 8 INFLAMMASOMES AND INFLAMMATION; NOD-LIKE RECEPTORS AND THE INFLAMMASOMES; THE NLRP3 INFLAMMASOME; THE IPAF INFLAMMASOME; THE NLRP1 INFLAMMASOME; THE NLRP12 INFLAMMASOME; THE NLRP7 INFLAMMASOME; THE NLRP6 INFLAMMASOME; THE AIM2 INFLAMMASOME; CYTOKINE TARGETS OF THE INFLAMMASOME; INFLAMMASOME DYSREGULATION IN DISEASE; CONCLUDING REMARKS; REFERENCES; CHAPTER 9 ACTIVATION-INDUCED CYTIDINE DEAMINASE: AN INTRINSIC GENOME MODULATOR IN INFLAMMATION-ASSOCIATED CANCER DEVELOPMENT Print version record and CIP data provided by publisher. Carcinogenesis. Inflammation Mediators. Inflammation Immunological aspects. Cancer Immunological aspects. Neoplasms genetics. HEALTH & FITNESS Diseases General. bisacsh MEDICAL Clinical Medicine. bisacsh MEDICAL Diseases. bisacsh MEDICAL Evidence-Based Medicine. bisacsh MEDICAL Internal Medicine. bisacsh Cancer Immunological aspects. fast (OCoLC)fst00845383 Carcinogenesis. fast (OCoLC)fst00846974 Inflammation Immunological aspects. fast (OCoLC)fst00972435 Inflammation Mediators. fast (OCoLC)fst00972436 Inflammation - Immunological aspects. Electronic books. Electronic books. Hiraku, Yūsuke, editor. Kawanishi, Shōsuke, 1942- editor. Ōshima, Hiroshi, 1949- editor. Print version: Cancer and inflammation mechanisms. Hoboken, New Jersey : Wiley, [2014] 9781118160305 (DLC) 2013035524 (OCoLC)859252945 http://onlinelibrary.wiley.com/book/10.1002/9781118826621 Wiley Online Library ddc BK 207015 207015