06330cam a2200757 i 4500 ocn858914538 OCoLC 20171106082851.0 m o d cr ||||||||||| 130923s2013 nju ob 001 0 eng 2013038614 016472662 Uk 9781118300343 (epub) 1118300343 (epub) 9781118300411 (pdf) 1118300416 (pdf) 9781118300268 ( mobi) 1118300262 ( mobi) 9781118300398 (cloth : alk. paper) 9781118300312 1118300319 1118300394 9781118300398 9781306090919 1306090911 AU@ 000051986242 CHBIS 010131766 CHVBK 314703063 NZ1 15341509 DEBSZ 431552738 GBVCP 790210428 DEBBG BV043396235 (OCoLC)858914538 (OCoLC)927507527 DLC eng rda DLC YDX IDEBK EBLCP YDXCP CUS DG1 N$T UKMGB CDX COO NLGGC DEBSZ OCLCQ DEBBG pcc MAIN QP623.5.S63 QU 58.7 SCI 007000 bisacsh 572.8/8 23 MicroRNAs in medicine / edited by Charles H. Lawrie. [electronic resource] Hoboken, New Jersey : Wiley-Blackwell, [2013] 1 online resource. text rdacontent computer rdamedia online resource rdacarrier Includes bibliographical references and index. ""Title page""; ""Copyright page""; ""Foreword""; ""Preface""; ""Contributors""; ""1: MicroRNAs: A Brief Introduction""; ""I. A Short History of Small RNAs""; ""II. Biogenesis of miRNAs""; ""III. miRNA Function: Controlling mRNA Stability, Degradation, and/or Translation""; ""IV. Regulating the Regulators: miRNA Control and Dysfunction in Disease""; ""V. Present and Future Perspectives for miRNAs in Medicine""; ""PART I: MicroRNAs as Physiological Regulators""; ""2: MicroRNA Regulation of Stem Cell Fate and Reprogramming""; ""I. Introduction"" ""II. MicroRNAs in Pluripotency and Establishment of Different Lineages""""III. MicroRNAs, Induced Pluripotency, and Transdifferentiation""; ""IV. Conclusion""; ""Acknowledgments""; ""3: MicroRNAs as Regulators of Immunity""; ""I. Introduction""; ""II. Innate Immunity and miRNAs""; ""III. Adaptive Immunity and miRNAs""; ""IV. Conclusions and Future Directions""; ""4: Regulation of Senescence by MicroRNAs""; ""I. Introduction: Senescence""; ""II. Posttranscriptional Regulation of Senescence by miRNAs""; ""III. Impact of SA-miRNAs on In Vivo Senescence"" ""IV. Concluding Remarks and Future Perspectives""""Acknowledgments""; ""5: The Emergence of GeroMIRs: A Group of MicroRNAs Implicated in Aging""; ""I. Introduction""; ""II. MiRNAs and Aging: Lessons from Invertebrates""; ""III. Changes in miRNA Expression during Mammalian Aging""; ""IV. MiRNA Modulation of Mammalian DNA Damage""; ""V. Micromanaging of Other Aging-Associated Pathways in Mammals""; ""VI. Conclusions and Future Perspectives""; ""6: MicroRNAs and Hematopoiesis""; ""I. Introduction""; ""II. Lymphocyte Development""; ""III. Monocyte and Granulocyte Development"" ""IV. Erythrocyte and Megakaryocyte Development""""V. Conclusions""; ""7: MicroRNAs in Platelet Production and Activation""; ""I. Introduction""; ""II. miRNA Biogenesis and Function""; ""III. miRNAs and Megakaryocytopoiesis""; ""IV. Platelet miRNAs""; ""V. Platelet miRNAs as Biomarkers""; ""VI. Platelet Microparticles and miRNAs""; ""VII. Summary and Future Directions""; ""PART II: MicroRNAs in Infectious Disease: Hostâ€"Pathogen Interactions""; ""8: MicroRNAs as Key Players in Host-Virus Interactions""; ""I. Introduction""; ""II. Host miRNAs and Virus Infection""; ""III. Viral miRNAs"" ""IV. Biological Roles of Viral miRNAs""""V. Conclusions and Future Prospects""; ""Acknowledgments""; ""9: MicroRNA Expression in Avian Herpesviruses""; ""I. Introduction""; ""II. Avian Herpesviruses and Associated Diseases""; ""III. Identification of miRNAs Encoded by Avian HerpesvirusES""; ""IV. Viral Orthologues of Host miRNAs""; ""V. Target Identification of Avian Herpesvirus miRNAs""; ""VI. Conclusions""; ""Acknowledgment""; ""10: Function of Human Cytomegalovirus MicroRNAs and Potential Roles in Latency""; ""I. Introduction to Human Cytomegalovirus"" "MicroRNAs in Medicine provides an access point into the current literature on microRNA for both scientists and clinicians, with an up-to-date look at what is happening in the emerging field of microRNAs and their relevance to medicine. Each chapter is a comprehensive review, with descriptions of the latest microRNA research written by international leaders in their field. Opening with an introduction to what microRNAs are and how they function, the book goes on to explore the role of microRNAs in normal physiological functions, infectious diseases, non-infectious diseases, cancer, circulating microRNAs as non-invasive biomarkers, and finally their potential as novel therapeutics.Including background information on the field as well as reviews of the latest research breakthroughs, MicroRNAs in Medicine is a one-stop source of information to satisfy the specialists and non-specialists alike, appealing to students, researchers, and clinicians interested in understanding the potential of microRNAs in medicine and research"--Provided by publisher. Description based on print version record and CIP data provided by publisher. MicroRNAs. Small interfering RNA. Small interfering RNA Therapeutic use. SCIENCE Life Sciences Biochemistry. bisacsh Electronic books. Electronic books. Lawrie, Charles H., editor of compilation. Print version: MicroRNAs in medicine Hoboken, New Jersey : Wiley-Blackwell, [2013] 9781118300398 (DLC) 2013038052 http://onlinelibrary.wiley.com/book/10.1002/9781118300312 Wiley Online Library ddc BK 206998 206998