03684cam a2200601Ia 4500 ocn858657953 OCoLC 20171106090027.0 m o d cr |n||||||||| 130920s2014 gw a ob 001 0 eng d 9783527659685 (electronic bk.) 3527659684 (electronic bk.) 1299854656 (ebk) 9781299854659 (ebk) 9783527659715 (e-book) 3527659714 (e-book) 9783527333059 (hbk.) 3527333053 (hbk.) AU@ 000052185441 CHBIS 010131729 CHVBK 314712992 DEBBG BV041407601 GBVCP 79020990X NZ1 15497579 NZ1 15697421 NZ1 15905608 (OCoLC)858657953 516716 MIL IDEBK eng pn IDEBK OCLCQ E7B DG1 CUS YDXCP DEBBG OCLCF UBY NLGGC OCLCQ COO OCLCQ MAIN RM267 615.7/922 23 Antibiotics : targets, mechanisms and resistance / edited by Claudio O. Gualerzi [and others]. [electronic resource] Weinheim, Germany : Wiley-VCH, ©2014. 1 online resource (xxiv, 549 pages) : illustrations (some color) text txt rdacontent computer c rdamedia online resource cr rdacarrier Includes bibliographical references and index. A chemist's survey of different antibiotic classes -- Antibacterial discovery: problems and possibilities -- Impact of microbial natural products on antibacterial drug discovery -- Antibiotics and resistance: a fatal attraction -- Fitness costs of antibiotic resistance -- Inhibitors of cell-wall synthesis -- Inhibitors of bacetrial cell partitioning -- The membrane as a novel target site for antibiotics to kill persisting bacterial pathogens -- Bacterial membrane, a key for controlling drug influx and efflux -- Interference with bacterial cell-to-cell chemical signaling in development of new anti-infectives -- Recent developments in inhibitors of bacterial type IIA topoisomerases -- Antibiotics targeting bacterial RNA polymerase -- Inhibitors targeting riboswitches and ribozymes -- Targeting ribonuclease P -- Involvement of ribosome biogenesis in antibiotic functions, acquired resistance, and future opportunities in drug discovery -- Aminoacyl-tRNA synthetase inhibitors -- Antibiotics targeting translation initiation in prokaryotes -- Inhibitors of bacterial elongation factor EF-Tu -- Aminoglycoside antibiotics: structural decoding of inhibitors targeting the ribosomal decoding A site -- Reptidyltransferase inhibitors of the bacterial ribosome -- Antibiotics inhibiting the translocation step of protein elongation on the ribosome -- Antibiotics at the ribosomal exit tunnel -- selected structual aspects -- Targeting HSP70 to fight cancer and bad bugs: one and the same battle? Online resource; title from PDF title page (Wiley, viewed November 4, 2013). Antibiotics. Antibiotics Physiological effect. Anti-Bacterial Agents. Antibiotics. fast (OCoLC)fst00810420 Antibiotics Physiological effect. fast (OCoLC)fst00810431 Electronic books. Gualerzi, Claudio O., 1942- Print version: Antibiotics. Weinheim : Wiley-VCH, 2013 9783527333059 (OCoLC)856201915 http://onlinelibrary.wiley.com/book/10.1002/9783527659685 Wiley Online Library ddc BK 206988 206988