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  <titleInfo>
    <title>Synthetic methods for biologically active molecules : exploring the potential of bioreductions</title>
  </titleInfo>
  <name type="personal">
    <namePart>Brenna, Elisabetta.</namePart>
  </name>
  <typeOfResource>text</typeOfResource>
  <genre authority="marc">bibliography</genre>
  <genre authority="">Electronic books.</genre>
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    <place>
      <placeTerm type="code" authority="marccountry">gw</placeTerm>
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    <dateIssued encoding="marc">2013</dateIssued>
    <copyrightDate encoding="marc">2014</copyrightDate>
    <issuance>monographic</issuance>
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  <language>
    <languageTerm authority="iso639-2b" type="code">eng</languageTerm>
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    <extent>1 online resource (xviii, 387 pages) : illustrations</extent>
  </physicalDescription>
  <abstract>This ready reference focuses on the currently available toolbox of biocatalysed reductions of C=O, C=C and formal C=N double bonds to show which transformations are reliable for use in manufacturing processes and which still require improvements and investigation. Following an introductory chapter, chapters 2-4 present the synthetic strategies which are currently available for the reduction of C=C, C=O and for reductive amination, by means of whole cell catalysts and isolated enzymes.</abstract>
  <tableOfContents>Development of Sustainable Biocatalytic Reduction Processes for Organic Chemists / Roland Wohlgemuth -- Reductases: From Natural Diversity to Established Biocatalysis and to Emerging Enzymatic Activities / Elena Fernández-Álvaro, Pablo Domínguez de María -- Synthetic Strategies Based on C=C Bioreductions for the Preparation of Biologically Active Molecules / Francesco G Gatti, Fabio Parmeggiani, Alessandro Sacchetti -- Synthetic Strategies Based on C=O Bioreductions for the Preparation of Biologically Active Molecules / Aníbal Cuetos, Alba Díaz-Rodríguez, Iván Lavandera -- Protein Engineering: Development of Novel Enzymes for the Improved Reduction of C=C Double Bonds / Sabrina Kille, Manfred T Reetz -- Protein Engineering: Development of Novel Enzymes for the Improved Reduction of C=O Double Bonds / Nobuya Itoh, Yoshihide Makino -- Synthetic Applications of Aminotransferases for the Preparation of Biologically Active Molecules / Sachin Pannuri, Sanjay Kamat, Abraham R Mártin-García -- Strategies for Cofactor Regeneration in Biocatalyzed Reductions / Selin Kara, Joerg H Schrittwieser, Frank Hollmann -- Solvent Effects in Bioreductions / Yan Ni, Hui-Lei Yu, Jian-He Xu -- Application of Product Removal (ISPR) Technologies for Implementation and Scale-Up of Biocatalytic Reductions / John M Woodley -- Bioreductions in Multienzymatic One-Pot and Cascade Processes / Daniela Monti, Erica E Ferrandi -- Dynamic Kinetic Resolutions Based on Reduction Processes / Dimitris Kalaitzakis, Ioulia Smonou -- Relevant Practical Applications of Bioreduction Processes in the Synthesis of Active Pharmaceutical Ingredients / Gábor Tasnádi, Mélanie Hall.</tableOfContents>
  <note type="statement of responsibility">edited by Elisabetta Brenna.</note>
  <note>Includes bibliographical references and index.</note>
  <note>Text in English.</note>
  <subject authority="lcsh">
    <topic>Reduction (Chemistry)</topic>
  </subject>
  <subject authority="lcsh">
    <topic>Bioactive compounds</topic>
    <topic>Synthesis</topic>
  </subject>
  <subject authority="lcsh">
    <topic>Enzymes</topic>
    <topic>Biotechnology</topic>
  </subject>
  <subject authority="lcsh">
    <topic>Enzymes</topic>
    <topic>Industrial applications</topic>
  </subject>
  <subject authority="bisacsh">
    <topic>SCIENCE</topic>
    <topic>Physics</topic>
    <topic>Crystallography</topic>
  </subject>
  <subject authority="fast">
    <topic>Biochemistry</topic>
  </subject>
  <subject authority="fast">
    <topic>Biomolecules</topic>
  </subject>
  <classification authority="lcc">QD461</classification>
  <classification authority="ddc">548.478</classification>
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    <titleInfo>
      <title>Synthetic methods for biologically active molecules</title>
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    <originInfo>
      <publisher>Weinheim : Wiley-VCH, 2013</publisher>
    </originInfo>
    <identifier type="local">(OCoLC)856201927</identifier>
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  <identifier type="isbn">9783527665785</identifier>
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  <identifier type="stock number">514275 MIL</identifier>
  <identifier type="uri">http://onlinelibrary.wiley.com/book/10.1002/9783527665785</identifier>
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    <recordChangeDate encoding="iso8601">20171106090201.0</recordChangeDate>
    <recordIdentifier source="OCoLC">ocn857365390</recordIdentifier>
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