06733cam a2200829Ia 4500 ocn851315970 OCoLC 20171106094934.0 m o d cr cnu|||unuuu 130629s2013 iau ob 001 0 eng d 9781118453902 (electronic bk.) 1118453905 (electronic bk.) 9781118453926 (electronic bk.) 1118453921 (electronic bk.) 1118453883 (softback ; alk. paper) 9781118453889 (softback ; alk. paper) 9781118453896 (eMobi) 1118453891 (eMobi) 9781118453919 (ePub) 1118453913 (ePub) 9781118453889 AU@ 000053306419 DEBBG BV041572225 DKDLA 820120-katalog:000665241 GBVCP 790209012 NZ1 15340395 DEBBG BV043396055 (OCoLC)851315970 (OCoLC)868940046 EBLCP eng pn EBLCP OCLCQ N$T DG1 CUI NOC OCLCQ YDXCP OHI OCLCF OCLCQ NLGGC E7B WIC OCLCQ COO OCLCQ MAIN RC931.M45 HEA 039100 bisacsh MED 065000 bisacsh MED 083000 bisacsh 616.7/16 616.716 22 Primer on the metabolic bone diseases and disorders of mineral metabolism / editor-in-chief, Clifford J. Rosen ; senior associate editors, Roger Bouillon, Juliet E. Compston, Vicki Rosen ; associate editors, Douglas P. Bauer [and others]. [electronic resource] 8th ed. Ames, Iowa : Wiley-Blackwell, 2013. 1 online resource (xxvi, 1078 pages) text txt rdacontent computer c rdamedia online resource cr rdacarrier Includes bibliographical references at the end of each chapters and index. Cover; Title page; Copyright page; Contents; Contributors; Primer Corporate Sponsors; Preface to the Eighth Edition of the Primer; About ASBMR; President's Preface; About the Companion Website; Section I: Molecular Cellular and Genetic Determinants of Bone Structure and Formation; 1: Skeletal Morphogenesis and Embryonic Development; Early Skeletal Patterning; Craniofacial patterning; Axial patterning; Limb patterning; Embryonic Cartilage and Bone Formation; Chondrocyte Proliferation and Differentiation in The Developing Cartilage; Regulation of Chondrocyte Survival; Conclusions; References. 2: Signal Transduction Cascades Controlling Osteoblast Differentiation; Introduction; Runx2 and Osterix Transcription Factors; BMP Signaling; TGF-ß Signaling; WNT Signaling; Hedgehog Signaling; PTH Signaling; IGF-1 Signaling; FGF Signaling; Notch Signaling; Concluding Remarks; Acknowledgments; References; 3: Osteoclast Biology and Bone Resorption; Cell Biology of The Osteoclast; Integrin Signaling; Small GTPases; Factors Regulating Osteoclast Formation And/Or Function; Proteins; Small molecules; Cell-Cell Interactions in Bone Marrow; Intracellular Signaling Pathways; Human Genetics; References. 4: Osteocytes; Introduction; Osteocyte Ontogeny; Osteocytes as Orchestrators of Bone (Re)Modeling; Osteocyte Cell Death and Apoptosis; Osteocyte Modification of Their Microenvironment; Mechanosensation and Transduction; Role of Gap Junctions and Hemichannels in Osteocyte Communication; The Potential Role of Osteocytes in Bone Disease; Acknowledgment; References; 5: Connective Tissue Pathways That Regulate Growth Factors; Introduction; The Fibrillinopathies; Fibrillin Microfibrils; Regulation of Growth Factors by Fibrillin Microfibrils; Molecular Mechanisms Orchestrated on a Microfibril Scaffold. Abbreviations; References; 6: The Composition of Bone; Introduction; The Composite; The mineral; Collagen; Noncollagenous Proteins; Serum-derived proteins; Proteoglycans; Glycosylated proteins; Small integrin-binding ligand, N-glycosylated protein, and other glycoproteins with cell attachment activity; Gla-containing proteins; Other Components; References; 7: Assessment of Bone Mass and Microarchitecture in Rodents; Introduction; Radiographs; Peripheral Dual-Energy X-Ray Absorptiometry; Peripheral Quantitative Computed Tomography; Magnetic Resonance Imaging; Microcomputed Tomography. Nanocomputed Tomography; Imaging Considerations; Voxel size and image resolution; Segmentation; Skeletal site and volume of interest; Calibration; Other considerations; Conclusions; References; 8: Animal Models: Genetic Manipulation; Introduction; Overexpression of Target Genes; Chondrocytes; Osteoblasts; Tendon and ligament; Osteoclasts; Advantages and disadvantages of overexpression approaches; Gene Targeting; Advantages and disadvantages of gene targeting; Tissue-Specific and Inducible Knockout and Overexpression; Uncondensed mesenchyme, mesenchymal condensations, and neural crest; Cartilage; Osteoblasts. Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism, 8th Edition is the comprehensive revision of the field-leading reference on bone and mineral health. The eighth edition has been fully revised by the leading researchers and clinicians in the field to provide concise coverage of the widest possible spectrum of metabolic bone diseases and disorders of mineral metabolism. Chapters look to explain basic biological factors of healthy development and disease states and make it easily translatable to clinical interventions. Print version record. Bones Metabolism Disorders. Mineral metabolism Disorders. Bones Diseases. Bone Diseases, Metabolic. Bone and Bones metabolism. Minerals metabolism. HEALTH & FITNESS Diseases Musculoskeletal. bisacsh MEDICAL Orthopedics. bisacsh MEDICAL Rheumatology. bisacsh Bones Diseases. fast (OCoLC)fst00836004 Bones Metabolism Disorders. fast (OCoLC)fst00836025 Mineral metabolism Disorders. fast (OCoLC)fst01022354 Electronic books. Rosen, Clifford J. Bouillon, R. Compston, Juliet. Rosen, Vicki. Print version: Primer on the metabolic bone diseases and disorders of mineral metabolism. 8th ed. Ames, Iowa : Wiley-Blackwell, 2013 9781118453889 (DLC) 2013002831 (OCoLC)826287961 http://onlinelibrary.wiley.com/book/10.1002/9781118453926 Wiley Online Library ddc BK 206864 206864