Sierra, Miguel A. (Miguel Angel) creator author. Torre, María C. de la author. Cossío, Fernando P. author. text bibliography Electronic books. Electronic books. gw 2013 2013 First edition. monographic eng

electronic resource

1 online resource (xxi, 266 pages) : illustrations Success comes in many forms and in synthesis it can be a failure that results in their ultimate successful solutions. This long-awaited sequel to "Dead Ends and Detours" retains the proven concept while featuring over 20 new case studies of failed strategies and their (successful) solutions in natural product total synthesis. Additionally, computational models are used to discuss the problem in much more detail and to provide readers with additional information not found in the primary literature. The topics range from classic synthetic reactions (e.g. Diels Alder reaction), metal-mediated coupling reactions, metathesis, and asymmetric catalysis to the importance of protecting and activating groups. This book will benefit not only graduate students in organic chemistry but also advanced researchers as they gain knowledge derived from the step-by-step analysis of mistakes made in the past and, thus be able to improve their own chemical reaction planning. With its coverage of the most commonly applied reaction types, the book perfectly complements its predecessor, which focuses on general aspects, such as reactivity and selectivity. The Inertia of Conventional Functional Groups -- The Diels-Alder Reaction -- The Aldol Condensation -- Cyclizations: Concerted, Radical, or Polar? -- Macrocycles: From Reluctant Ring Closure to Reluctant Ring Opening -- Stereochemistry, Controlled or Uncontrolled? -- Transition Metal-Mediated Transformations vs "Conventional" Reactions -- When Metathesis Fails -- Oxidations in C-C Bond Building -- The Failure of Epoxide Ring Opening and the Limits of Cascade Reactions. Miguel A. Sierra, María C. de la Torre, and Fernando P. Cossío. Edition statement from first page of chapter PDFs. Includes bibliographical references and index. Organic compounds Synthesis SCIENCE Chemistry Organic Organic compounds Synthesis QD262 .S54 2013 547/.2 Sierra, Miguel A. Weinheim : Wiley-Vch, 2013 (OCoLC)823380609 9783527654628 3527654623 9783527654659 3527654658 9783527654642 352765464X 9783527654635 3527654631 9783527654628 1299738109 9781299738102 505061 MIL http://onlinelibrary.wiley.com/book/10.1002/9783527654628 http://onlinelibrary.wiley.com/book/10.1002/9783527654628 DG1 130605 20171106103140.0 ocn846849851 eng