04425cam a2200733Ia 4500 ocn846849851 OCoLC 20171106103140.0 m o d cr cn||||||||| 130605t20132013gw a ob 001 0 eng d 016329591 Uk 9783527654628 (electronic bk.) 3527654623 (electronic bk.) 9783527654659 (ePDF) 3527654658 (ePDF) 9783527654642 (ePub) 352765464X (ePub) 9783527654635 (mobi) 3527654631 (mobi) 9783527654628 (oBook) 1299738109 9781299738102 9783527329762 (Print) 3527329765 (Print) AU@ 000051629093 DEBBG BV041292224 DEBBG BV041829473 DEBBG BV041904709 DKDLA 820120-katalog:000696819 GBVCP 790208199 NZ1 15340109 (OCoLC)846849851 (OCoLC)855905996 (OCoLC)895736998 (OCoLC)961669377 (OCoLC)962586747 505061 MIL DG1 eng pn DG1 CUS OCLCO UKMGB YDXCP N$T NOC E7B OCLCO OCLCF IUL OCLCQ COO CN3GA IDEBK CDX DEBBG OCLCQ LOA MAIN QD262 .S54 2013 SCI 013040 bisacsh 547/.2 23 Sierra, Miguel A. (Miguel Angel), author. More dead ends and detours : en route to successful total synthesis / Miguel A. Sierra, María C. de la Torre, and Fernando P. Cossío. [electronic resource] First edition. Weinheim, Germany : Wiley-VCH Verlag GmbH & Co. KGaA, 2013. ©2013 1 online resource (xxi, 266 pages) : illustrations text txt rdacontent computer c rdamedia online resource cr rdacarrier Edition statement from first page of chapter PDFs. Includes bibliographical references and index. The Inertia of Conventional Functional Groups -- The Diels-Alder Reaction -- The Aldol Condensation -- Cyclizations: Concerted, Radical, or Polar? -- Macrocycles: From Reluctant Ring Closure to Reluctant Ring Opening -- Stereochemistry, Controlled or Uncontrolled? -- Transition Metal-Mediated Transformations vs "Conventional" Reactions -- When Metathesis Fails -- Oxidations in C-C Bond Building -- The Failure of Epoxide Ring Opening and the Limits of Cascade Reactions. Success comes in many forms and in synthesis it can be a failure that results in their ultimate successful solutions. This long-awaited sequel to "Dead Ends and Detours" retains the proven concept while featuring over 20 new case studies of failed strategies and their (successful) solutions in natural product total synthesis. Additionally, computational models are used to discuss the problem in much more detail and to provide readers with additional information not found in the primary literature. The topics range from classic synthetic reactions (e.g. Diels Alder reaction), metal-mediated coupling reactions, metathesis, and asymmetric catalysis to the importance of protecting and activating groups. This book will benefit not only graduate students in organic chemistry but also advanced researchers as they gain knowledge derived from the step-by-step analysis of mistakes made in the past and, thus be able to improve their own chemical reaction planning. With its coverage of the most commonly applied reaction types, the book perfectly complements its predecessor, which focuses on general aspects, such as reactivity and selectivity. Online resource; title from PDF title page (viewed May 7, 2014). Organic compounds Synthesis. SCIENCE Chemistry Organic. bisacsh Organic compounds Synthesis. fast (OCoLC)fst01047668 Electronic books. Electronic books. local Torre, María C. de la, author. Cossío, Fernando P., author. Print version: Sierra, Miguel A. More dead ends and detours. Weinheim : Wiley-Vch, 2013 3527329765 (OCoLC)823380609 http://onlinelibrary.wiley.com/book/10.1002/9783527654628 Wiley Online Library ddc BK 206802 206802