04975cam a2200781Ma 4500 ocn828743731 OCoLC 20171107092059.0 m o d cr cn||||||||| 130211s2013 gw a ob 001 0 eng d 9783527648238 (e-book) 3527648232 (e-book) 9783527648207 3527648208 9783527331079 3527331077 (Cloth) 9781283993630 (MyiLibrary) 1283993635 (MyiLibrary) AU@ 000051629472 AU@ 000053300824 CHBIS 010026776 CHVBK 306233339 DEBBG BV041905749 DKDLA 820120-katalog:000651464 NZ1 15340084 ZWZ 178874590 DEBBG BV043395536 (OCoLC)828743731 (OCoLC)827208435 (OCoLC)827243162 (OCoLC)961611329 (OCoLC)962590926 E7B eng pn E7B OCLCO OCLCQ CDX COO N$T YDXCP CUS IDEBK DG1 NOC OCLCF IUL EBLCP K6U DEBBG OCLCQ MAIN QP551.5 .P76 2013eb QV 744 HEA eflch MED 023000 bisacsh MED 058170 bisacsh MED 071000 bisacsh MED 072000 bisacsh 615.19 23 Protein-protein interactions in drug discovery / edited by Alexander Dömling. [electronic resource] Weinheim : Wiley-VCH, 2013. 1 online resource (xxi, 314 pages) : illustrations. text txt rdacontent computer c rdamedia online resource cr rdacarrier Methods and principles in medicinal chemistry ; v. 56 Includes bibliographical references and index. Protein-protein interactions: an vverview / Christian Ottman -- Prediction of intra- and interspecies protein-protein interactions facilitating systems biology studies / Sylvia Schleker, Seshan Ananthasubramanian, Judith Klein-Seetharaman, Madhavi K Ganapathiraju -- Modulators of protein-protein interactions: importance of three-dimensionality / David C Fry, Sung-Sau So -- A leap into the chemical space of protein-protein interaction inhibitors / Bruno O Villoutreix, C Labbé, David Lagorce, Guillaume Laconde, Olivier Sperandio -- Interactive technologies for leveraging the known chemistry of anchor residues to disrupt protein interactions / Carlos J Camacho, David R Koes, Alexander S Dömling -- SH3 domains as drug targets / James Luccarelli, Sam Thompson, Andrew D Hamilton -- p53/MDM2 antagonists: towards nongenotoxic anticancer treatments / Kareem Khoury, Tad A Holak, Alexander Dömling -- Inhibition of LFA-1/ICAM interaction for the treatment of autoimmune diseases / Kevin M Guckian, Daniel M Scott -- The PIF pocket of AGC kinases: a target site for allosteric modulators and protein-protein interaction inhibitors / Matthias Engel -- Retosiban and epelsiban: potent and selective orally available oxytocin antagonists / Alan D Borthwick, John Liddle -- Peptidic inhibitors of protein-protein interactions for cell adhesion receptors: RGD peptides and beyond / Carlos Mas-Moruno, Horst Kessler -- REPLACE strategy for generating non-ATP-competitive inhibitors of cell cycle protein kinases / Campbell McInnes -- Index. Treating protein-protein interactions as a novel and highly promising class of drug targets, this volume introduces the underlying strategies step by step, from the biology of PPIs to biophysical and computational methods for their investigation. The main part of the book describes examples of protein targets for which small molecule modulators have been developed, covering such diverse fields as cancer, autoimmune disorders and infectious diseases. Tailor-made for the practicing medicinal chemist, this ready reference includes a wide selection of case studies taken straight from the devel. Protein-protein interactions. Protein binding. Proteins Inhibitors. Protein binding. Protein-protein interactions. Proteins Inhibitors. MEDICAL Drug Guides. bisacsh MEDICAL Nursing Pharmacology. bisacsh MEDICAL Pharmacology. bisacsh MEDICAL Pharmacy. bisacsh Drugs Design. fast (OCoLC)fst00898790 Protein-protein interactions. fast (OCoLC)fst01079705 Electronic books. Dömling, Alexander. Print version: Protein-protein interactions in drug discovery. Weinheim : Wiley-VCH Verlag GmbH, 2013 9783527331079 Methods and principles in medicinal chemistry ; v. 56. http://onlinelibrary.wiley.com/book/10.1002/9783527648207 Wiley Online Library ddc BK 206517 206517