05275cam a2200733Ii 4500 ocn826637765 OCoLC 20171112083120.0 m o d cr cnu|||unuuu 130204t20132013gw ac ob 001 0 eng d 9783527651085 (electronic bk.) 352765108X (electronic bk.) 9783527651115 (electronic bk.) 352765111X (electronic bk.) 9781299241206 (MyiLibrary) 1299241204 (MyiLibrary) 9783527330737 3527330739 AU@ 000050562533 AU@ 000053030546 DKDLA 820120-katalog:000655918 NLGGC 382514440 NZ1 15340091 DEBBG BV043395341 (OCoLC)826637765 (OCoLC)828869678 (OCoLC)828896125 (OCoLC)961601655 (OCoLC)962705463 455370 MIL DG1 eng rda pn DG1 EBLCP N$T MHW YDXCP COO IDEBK E7B NOC OCLCF IUL SCB OCLCQ CDX NKT OCLCQ MAIN RM301.25 .A53 2013 MED 023000 bisacsh MED 058170 bisacsh MED 071000 bisacsh MED 072000 bisacsh HEA eflch 615.1/9 23 Analogue-based drug discovery III / edited by János Fischer, C. Robin Ganellin, David P. Rotella. [electronic resource] Analogue-based drug discovery 3 Analog-based drug discovery III Weinheim : Wiley-VCH, [2013] ©2013 1 online resource (xviii, 385 pages) : illustrations, portraits text txt rdacontent computer c rdamedia online resource cr rdacarrier Includes bibliographical references and index. General Aspects. Pioneer and Analogue Drugs / Janos Fischer, C Robin Ganellin, David P Rotella -- Competition in the Pharmaceutical Drug Development / Christian Tyrchan, Fabrizio Giordanetto -- Metabolic Stability and Analogue-Based Drug Discovery / Amit S Kalgutkar, Antonia F Stepan -- Use of Macrocycles in Drug Design Exemplified with Ulimorelin, a Potential Ghrelin Agonist for Gastrointestinal Motility Disorders / Mark L Peterson, Hamid Hoveyda, Graeme Fraser, Eric Marsault, Rene Gagnon -- Drug Classes. The Discovery of Anticancer Drugs Targeting Epigenetic Enzymes / A Ganesan -- Thienopyridyl and Direct-Acting P2Y Receptor Antagonist Antiplatelet Drugs / Joseph A Jakubowski, Atsuhiro Sugidachi -- Selective Estrogen Receptor Modulators / Amarjit Luniwal, Rachael Jetson, Paul Erhardt -- Discovery of Nonpeptide Vasopressin V2 Receptor Antagonists / Kazumi Kondo, Hidenori Ogawa -- The Development of Cysteinyl Leukotriene Receptor Antagonists / Peter R Bernstein -- Case Studies. The Discovery of Dabigatran Etexilate / Norbert Hauel, Andreas Clemens, Herbert Nar, Henning Priepke, Joanne van Ryn, Wolfgang Wienen -- The Discovery of Citalopram and Its Refinement to Escitalopram / Klaus P Bogeso, Connie Sanchez -- Tapentadol : From Morphine and Tramadol to the Discovery of Tapentadol / Helmut Buschmann -- Novel Taxanes: Cabazitaxel Case Study / Herve Bouchard, Dorothee Semiond, Marie-Laure Risse, Patricia Vrignaud -- Discovery of Boceprevir and Narlaprevir: A Case Study for Role of Structure-Based Drug Design / Srikanth Venkatraman, Andrew Prongay, George F Njoroge -- A New-Generation Uric Acid Production Inhibitor: Febuxostat / Ken Okamoto, Shiro Kondo, Takeshi Nishino. "Most drugs are analogue drugs. There are no general rules how a new drug can be discovered, nevertheless, there are some observations which help to find a new drug, and also an individual story of a drug discovery can initiate and help new discoveries. Volume III is a continuation of the successful book series with new examples of established and recently introduced drugs. The major part of the book is written by key inventors either as a case study or a study of an analogue class. With its wide range across a variety of therapeutic fields and chemical classes, this is of interest to virtually every researcher in drug discovery and pharmaceutical chemistry, and--together with the previous volumes--constitutes the first systematic approach to drug analogue development"--Publisher's website. Online resource; title page from PDF title page (viewed June 30, 2014). Drug development. MEDICAL Drug Guides. bisacsh MEDICAL Nursing Pharmacology. bisacsh MEDICAL Pharmacology. bisacsh MEDICAL Pharmacy. bisacsh Drug development. fast (OCoLC)fst00898670 Electronic books. Electronic books. local Fischer, János, editor. Ganellin, C. R. (C. Robin), editor. Rotella, David P., editor. Print version: Analogue-based drug discovery III. Weinheim : Wiley-VCH, [2013] 9783527330737 (OCoLC)825555931 http://onlinelibrary.wiley.com/book/10.1002/9783527651085 Wiley Online Library ddc BK 206390 206390