Korfmacher, Walter A. text bibliography Electronic books. nju Hoboken, N.J Wiley 2013 monographic eng

electronic resource

1 online resource (xii, 461 pages, [16] pages of plates)) : illustrations (some color). This book presents a summary of the ways mass spectrometry is used in various stages of drug discovery and development including early support of medicinal chemistry, drug metabolism studies, distribution, degradation, and various development assays. The book includes a balance of basic and advanced information. Specific chapters relate to various stages in the process (e.g., discovery) as well as chapters on topics of current interest (lipidomics and SiRNA) are covered. 1. Overview of the various types of mass spectrometers that are used in drug discovery and drug development / Gerard Hopfgartner -- 2. Utility of high resolution mass spectrometry for new drug discovery applications / William Bart Emary and Nanyan Rena Zhang -- 3. Quantitative mass spectrometry considerations in a regulated environment / Mohammed Jemal and Yuan-Qing Xia -- 4. Mass spectrometry for quantitative in vitro ADME assays / Jun Zhang and Wilson Z. Shou -- 5. Metabolite identification using mass spectrometry in drug development / Natalia Penner, Joanna Zgoda-Pols, and Chandra Prakash -- 6. MS analysis of biological drugs, proteins, and peptides / Yi Du, John Mehl, and Pavlo Pristatsky -- 7. Characterization of impurities and degradation products in small molecule pharmaceuticals and biologics / Hui Wei, Guodong Chen and Adrienne A. Tymiak -- 8. Liquid extraction surface analysis (LESA) : a new mass spectrometry-based technique for ambient surface profiling / Dan Eikel and Jack Henion -- 9. MS applications in support of medicinal chemistry sciences / Maarten Honing, Benno Ingelse, and Birendra˙ N. Pramanik -- 10. Imaging mass spectrometry of proteins and peptides / Michelle L. Reyzer and Richard M. Caprioli -- 11. Imaging mass spectrometry for drugs and metabolites / Stacey R. Oppenheimer -- 12. Screening reactive metabolites : role of liquid chromatography-high resolution mass spectrometry in combination with 'intelligent' data mining tools / Shuguang Ma and Swapan K. Chowdhury -- 13. Mass spectrometry of siRNA / Mark Cancilla and Mike Flanagan -- 14. Mass spectrometry for metabolomics / Petia Shipkova and Michael D. Reily -- 15. Quantitative analysis of peptides with mass spectrometry : selected reaction monitoring or high resolution full scan? / Lieve Dillen and Filip Cuyckens. edited by Walter A. Korfmacher. Includes bibliographical references and index. Drugs Analysis Drug development Mass spectrometry Drug Discovery Mass Spectrometry methods Peptides analysis Pharmaceutical Preparations analysis Proteins analysis Drug discovery Mass spectrometry Methods Peptides Analysis Pharmaceutical preparations Analysis Proteins Analysis MEDICAL Drug Guides MEDICAL Nursing Pharmacology MEDICAL Pharmacology MEDICAL Pharmacy Drug development Drugs Analysis Mass spectrometry RS189.5.S65 M37 2013eb 615.1 615.19 QV 744 Hoboken, N.J. : John Wiley & Sons, ©2013 (DLC) 2012031775 (OCoLC)806291832 9781118516157 111851615X 9781118516126 1118516125 9781283917520 1283917521 10.1002/9781118516157 Wiley InterScience http://onlinelibrary.wiley.com/book/10.1002/9781118516157 http://onlinelibrary.wiley.com/book/10.1002/9781118516157 MHW 121227 20171112123948.0 ocn823389939 eng