05462cam a2200853Ia 4500 ocn823389939 OCoLC 20171112123948.0 m o d cr |n||||||||| 121227s2013 njuaf ob 001 0 eng d 9781118516157 111851615X 9781118516126 1118516125 9781283917520 1283917521 9780470942383 047094238X AU@ 000050590993 DEBBG BV041049285 DEBBG BV041829130 DEBBG BV041908799 NZ1 15194662 NZ1 15340440 (OCoLC)823389939 (OCoLC)836200869 (OCoLC)860794225 10.1002/9781118516157 Wiley InterScience http://www3.interscience.wiley.com MHW eng pn MHW OCLCO EBLCP DG1 N$T YDXCP MYG CDX IDEBK IUL E7B NOC OCLCO OCLCF OCLCQ RECBK U3G UKDOC DEBBG COO OCLCQ MAIN RS189.5.S65 M37 2013eb QV 744 MED 023000 bisacsh MED 058170 bisacsh MED 071000 bisacsh MED 072000 bisacsh 615.1 615.19 Mass spectrometry for drug discovery and drug development / edited by Walter A. Korfmacher. [electronic resource] Hoboken, N.J. : Wiley, 2013. 1 online resource (xii, 461 pages, [16] pages of plates)) : illustrations (some color). text txt rdacontent computer c rdamedia online resource cr rdacarrier Wiley series on mass spectrometry Includes bibliographical references and index. 1. Overview of the various types of mass spectrometers that are used in drug discovery and drug development / Gerard Hopfgartner -- 2. Utility of high resolution mass spectrometry for new drug discovery applications / William Bart Emary and Nanyan Rena Zhang -- 3. Quantitative mass spectrometry considerations in a regulated environment / Mohammed Jemal and Yuan-Qing Xia -- 4. Mass spectrometry for quantitative in vitro ADME assays / Jun Zhang and Wilson Z. Shou -- 5. Metabolite identification using mass spectrometry in drug development / Natalia Penner, Joanna Zgoda-Pols, and Chandra Prakash -- 6. MS analysis of biological drugs, proteins, and peptides / Yi Du, John Mehl, and Pavlo Pristatsky -- 7. Characterization of impurities and degradation products in small molecule pharmaceuticals and biologics / Hui Wei, Guodong Chen and Adrienne A. Tymiak -- 8. Liquid extraction surface analysis (LESA) : a new mass spectrometry-based technique for ambient surface profiling / Dan Eikel and Jack Henion -- 9. MS applications in support of medicinal chemistry sciences / Maarten Honing, Benno Ingelse, and Birendraÿ N. Pramanik -- 10. Imaging mass spectrometry of proteins and peptides / Michelle L. Reyzer and Richard M. Caprioli -- 11. Imaging mass spectrometry for drugs and metabolites / Stacey R. Oppenheimer -- 12. Screening reactive metabolites : role of liquid chromatography-high resolution mass spectrometry in combination with 'intelligent' data mining tools / Shuguang Ma and Swapan K. Chowdhury -- 13. Mass spectrometry of siRNA / Mark Cancilla and Mike Flanagan -- 14. Mass spectrometry for metabolomics / Petia Shipkova and Michael D. Reily -- 15. Quantitative analysis of peptides with mass spectrometry : selected reaction monitoring or high resolution full scan? / Lieve Dillen and Filip Cuyckens. This book presents a summary of the ways mass spectrometry is used in various stages of drug discovery and development including early support of medicinal chemistry, drug metabolism studies, distribution, degradation, and various development assays. The book includes a balance of basic and advanced information. Specific chapters relate to various stages in the process (e.g., discovery) as well as chapters on topics of current interest (lipidomics and SiRNA) are covered. Print version record. Drugs Analysis. Drug development. Mass spectrometry. Drug Discovery. Mass Spectrometry methods. Peptides analysis. Pharmaceutical Preparations analysis. Proteins analysis. Drug discovery. Mass spectrometry Methods. Peptides Analysis. Pharmaceutical preparations Analysis. Proteins Analysis. MEDICAL Drug Guides. bisacsh MEDICAL Nursing Pharmacology. bisacsh MEDICAL Pharmacology. bisacsh MEDICAL Pharmacy. bisacsh Drug development. fast (OCoLC)fst00898670 Drugs Analysis. fast (OCoLC)fst00898769 Mass spectrometry. fast (OCoLC)fst01011435 Electronic books. Korfmacher, Walter A. Print version: Mass spectrometry for drug discovery and drug development. Hoboken, N.J. : John Wiley & Sons, ©2013 9780470942383 (DLC) 2012031775 (OCoLC)806291832 Wiley-Interscience series on mass spectrometry. http://onlinelibrary.wiley.com/book/10.1002/9781118516157 Wiley Online Library ddc BK 206325 206325