05661cam a2200589Mi 4500 ocn818819707 OCoLC 20171113091707.0 m o d cr cnu---unuuu 121120s2013 xx o 000 0 eng d 9781118468524 (electronic bk.) 111846852X (electronic bk.) 9781118354391 (electronic bk.) 1118354397 (electronic bk.) AU@ 000050207302 AU@ 000050635844 DEBBG BV041048987 NZ1 15915309 DEBBG BV043395199 (OCoLC)818819707 (OCoLC)819514468 EBLCP eng pn EBLCP N$T UIU OCLCQ DG1 OCLCF OCLCQ DEBBG D6H MAIN QK898.F5 F53 2013eb MED 071000 bisacsh 615.7 Flavonoid pharmacokinetics : methods of analysis, preclinical and clinical pharmacokinetics, safety, and toxicology / edited by Neal M. Davies, Jaime A. Yáñez. [electronic resource] Chicester : Wiley, 2013. 1 online resource (356 pages) text txt rdacontent computer c rdamedia online resource cr rdacarrier 6.3 Flavonoids and Hepatic Side Effects. Title page; Copyright page; Dedication; Contents; Foreword; Preface; Contributors; 1: Polyphenols and Flavonoids: An Overview; 1.1 Introduction; 1.2 Synthesis; 1.2.1 Synthesis of Flavonoids; 1.3 Sources; 1.4 Pharmacological Activities of Selected Flavonoids; 1.4.1 Hesperidin and Hesperetin; 1.4.2 Naringin and Naringenin; 1.4.3 Eriocitrin and Eriodictyol; 1.4.4 Phloretin; 1.4.5 Homoeriodictyol; 1.4.6 Isosakuranetin; 1.4.7 Taxifolin; 1.4.8 Sakuranetin; 1.4.9 Gallic Acid; 1.5 Conclusions; References; 2: Analysis of Flavonoids through Chromatography; 2.1 Introduction; 2.2 Polyphenols. 2.3 Chromatography2.3.1 Chromatographic Techniques; 2.3.2 Affinity Chromatography; 2.3.3 Ion-Exchange Chromatography; 2.3.4 Partition (Absorption); 2.3.5 Adsorption; 2.3.6 Paired Chromatography; 2.4 Detection; 2.4.1 Ultraviolet-Visible/Photodiode Array Detection; 2.4.2 Fluorescence Detection; 2.4.3 Mass Spectrometry; 2.4.4 Nuclear Magnetic Resonance; 2.4.5 Other Methods and Techniques; 2.5 Method Development; 2.5.1 Physicochemical Properties; 2.5.2 Mobile Phase; 2.5.3 Stationary Phase; 2.5.4 Internal and External Standards; 2.5.5 Processing; 2.6 Validation; 2.6.1 Peak Shape and Distribution. 2.6.2 Selectivity, Sensitivity, Accuracy, Precision, and Recovery2.6.3 Stability; 2.7 Summary; 2.8 Future Directions; 2.9 Conclusions; References; 3: Chiral Methods of Flavonoid Analysis; 3.1 Introduction; 3.2 Flavonoids and Chirality; 3.3 Separation of Enantiomers through Chromatography; 3.3.1 Chiral Stationary Phases (CSP) as Direct Methods; 3.3.2 Chiral Derivatization Techniques and Indirect Analysis; 3.4 Enantiomerization and Racemization; 3.5 Current Methods: Pros and Cons; 3.6 Flavanones; 3.6.1 Eriocitrin and Eriodictyol; 3.6.2 Flavanone; 3.6.3 Hesperidin and Hesperetin. 3.6.4 Homoeriodictyol3.6.5 Isosakuranetin; 3.6.6 Liquiritigenin; 3.6.7 Naringin and Naringenin; 3.6.8 Narirutin; 3.6.9 Neoeriocitrin; 3.6.10 Neohesperidin; 3.6.11 Pinocembrin; 3.6.12 Pinostrobin; 3.6.13 Prunin; 3.6.14 Sakuranetin; 3.6.15 Taxifolin; 3.6.16 6-Prenylnaringenin, 8-Prenylnaringenin, and Isoxanthohumol; 3.7 Catechins; 3.7.1 Catechin; 3.7.2 Catechin Gallate; 3.7.3 Epicatechin; 3.7.4 Epicatechin Gallate; 3.7.5 Epigallocatechin; 3.7.6 Epigallocatechin Gallate; 3.7.7 Gallocatechin; 3.8 Conclusions; References; 4: Preclinical Pharmacokinetics of Flavonoids; 4.1 Introduction. 4.2 Absorption4.3 Distribution; 4.4 Metabolism; 4.5 Excretion; 4.6 Conclusions; References; 5: Clinical Pharmacokinetics of Flavonoids; 5.1 Introduction; 5.2 Methods of Analysis; 5.3 Flavonoid Pharmacokinetics; 5.3.1 Nonchiral Flavonoids; 5.3.2 Chiral Flavonoids; 5.3.3 Flavonoid Derivatives; 5.4 Drug Interactions; 5.4.1 Effects of Flavonoids on Other Drug Pharmacokinetics; 5.4.2 Effects of Other Drugs on Flavonoid Pharmacokinetics; 5.5 Conclusions; References; 6: Toxicology and Safety of Flavonoids; 6.1 Introduction; 6.2 Flavonoids and the Gastrointestinal Tract; 6.2.1 Diarrhea; 6.2.2 Colitis. Highlighting the extremely important preclinical aspects of flavonoids, including pharmacokinetics and analysis in biological samples, Flavonoid Pharmacokinetics covers the methods of analysis and pharmacokinetics (preclinical and clinical) of flavonoids to help readers comprehend pharmacokinetic terminology, understand the large number of compounds that encompass the flavonoid family, appreciate the multiple analytical methods available, and assess preclinical and clinical pharmacokinetics of flavonoids and similar chemical-derived compounds. The book uses applicable examples in differ. Print version record. Flavonoids. Pharmacokinetics. MEDICAL Pharmacology. bisacsh Flavonoids. fast (OCoLC)fst00927101 Pharmacokinetics. fast (OCoLC)fst01060250 Electronic books. Davies, Neal M. Yáñez, Jaime A. Print version: Davies, Neal M. Flavonoid Pharmacokinetics : Methods of Analysis, Preclinical and Clinical Pharmacokinetics, Safety, and Toxicology. Chicester : Wiley, ©2012 9780470578711 http://onlinelibrary.wiley.com/book/10.1002/9781118468524 Wiley Online Library ddc BK 206265 206265