Bioisosteres in medicinal chemistry / [electronic resource] Brown, Nathan (Medicinal chemist) Mannhold, Raimund, 1948- Kubinyi, Hugo. Folkers, Gerd. Wiley InterScience (Online service) Drugs Design. Pharmaceutical chemistry. RS420 615/.19 22 References; Part Two: Data; 4 BIOSTER: A Database of Bioisosteres and Bioanalogues; 4.1 Introduction; 4.2 Historical Overview and the Development of BIOSTER; 4.2.1 Representation of Chemical Transformations for Reaction Databases; 4.2.2 The Concept of ''Biosteric Transformation''; 4.2.3 Other Analogue and Bioisostere Databases; 4.3 Description of BIOSTER Database; 4.3.1 Coverage and Selection Criteria; 4.3.2 Sources; 4.3.3 Description of the Layout of Database Records; 4.3.3.1 ID Code; 4.3.3.2 Biosteric Transformation; 4.3.3.3 Citation (s) ; 4.3.3.4 Activity; 4.3.3.5 Fragments. Print version record. Written with the practicing medicinal chemist in mind, this is the first modern handbook to systematically address the topic of bioisosterism. As such, it provides a ready reference on the principles and methods of bioisosteric replacement as a key tool in preclinical drug development. The first part provides an overview of bioisosterism, classical bioisosteres and typical molecular interactions that need to be considered, while the second part describes a number of molecular databases as sources of bioisosteric identification and rationalization. The third part covers the four key methodologi. Hoboken : John Wiley & amp ; Sons, 2012. 2012. 2012 Text 1 online resource. http://onlinelibrary.wiley.com/book/10.1002/9783527654307 eng Methods and principles in medicinal chemistry ; v. 54 Methods and principles in medicinal chemistry ; v. 54. Bioisosteres in medicinal chemistry. Bioisosteres in medicinal chemistry.