Anzenbacher, Pavel. Zanger, Ulrich M. 1955- Wiley InterScience (Online service) text bibliography Electronic books. gw Weinheim Wiley-VCH 2012 monographic eng

electronic resource

1 online resource (734 pages) A practice-oriented desktop reference for toxicologists and pharmaceutical researchers, this handbook provides systematic coverage of the metabolic pathways of all major classes of xenobiotics in the human body. The first part briefly reviews the main enzyme systems involved in biotransformation and how they are orchestrated in the body, while parts two to four cover the three main classes of xenobiotics: drugs, natural products, environmental pollutants. Selected, well-documented case studies from the most important xenobiotics classes illustrate general principles of metabolism, making this. Front Matter -- Biochemistry and Molecular Genetics of Drug Metabolism. Drug-Metabolizing Enzymes₆An Overview / Pavel Anzenbacher, Eva Anzenbacherov̀ -- Cytochromes P450 / F Peter Guengerich -- UDP-Glucuronosyltransferases / Christian P Strassburg, Sandra Kalthoff -- Sulfotransferases / Michael W H Coughtrie -- Glutathione -Transferases / Miroslav Dostalek, Anna-Katarina Stark -- Hydrolytic Enzymes / Bingfang Yan -- Transporting Systems / Anne T Nies, Claudia Resch, Tadashi Namisaki -- Transcriptional Regulation of Human Drug-Metabolizing Cytochrome P450 Enzymes / Zdenek Dvorak -- Importance of Pharmacogenomics / Ulrich M Zanger, Kathrin Klein, Jessica Rieger -- Metabolism of Drugs. Introduction to Drug Metabolism / Ulrich M Zanger -- Central Nervous System Drugs / Pierre Baumann, Christoph Hiemke -- Cardiovascular Drugs / Stephan Riedmaier, Ulrich M Zanger -- Anticancer Drugs / Matthias Schwab, Elke Schaeffeler, Hiltrud Brauch -- Antimicrobial Agents / Chantal Csajka, Oscar Marchetti, Oriol Manuel, Laurent Decosterd, Amalio Telenti -- Drugs against Acute and Chronic Pain / Andrew A Somogyi, Janet K Coller -- Drugs of Abuse (Including Designer Drugs) / Markus R Meyer, Hans H Maurer -- Nicotine Metabolism and its Implications / Andy Z X Zhu, Rachel F Tyndale -- Metabolism of Alcohol and its Consequences / Helmut K Seitz, Sebastian Mueller -- Metabolism of Natural Compounds. Introduction and Overview / Michael Murray -- Flavonoids / Petr Hodek -- St John's Wort (L.) / Miroslav Dostalek, Anna-Katarina Stark -- Food Components and Supplements / Alexandr Parlesak -- Metabolism of Unnatural Xenobiotics. Environmental Pollutants / Marie Stiborova -- Environmental Estrogens / Miroslav Machala, Jan Vondr̀cek -- Biotransformation of Insecticides / Corie A Ellison, Alice L Crane, James R Olson -- Index. specialized edited by Pavel Anzenbacher, Ulrich M. Zanger. Includes bibliographical references and index. Xenobiotics Metabolism Biotransformation (Metabolism) Toxicology Biotransformation physiology Xenobiotics metabolism Biological Agents metabolism Environmental Pollutants metabolism Pharmaceutical Preparations metabolism Pharmacokinetics Toxicology Biotransformation (Metabolism) Toxicology Xenobiotics Metabolism RA1211 615.9 QV 600 Weinheim : Wiley-VCH, 2012 (OCoLC)794620384 9783527630905 3527630902 9783527329038 352732903X 9783527630912 3527630910 9783527646326 3527646329 9783527646333 3527646337 9781280665653 1280665653 10.1002/9783527630905 Wiley InterScience http://onlinelibrary.wiley.com/book/10.1002/9783527630905 http://onlinelibrary.wiley.com/book/10.1002/9783527630905 DG1 120914 20171113140926.0 ocn809920135 eng