Civjan, Natanya editor. text bibliography Electronic books. Electronic books. nju 2012 2012 monographic eng

electronic resource

1 online resource (525 pages) : illustrations "Based on the award-winning Wiley Encyclopedia of Chemical Biology published in 2008, this book explores the role of chemical biology in drug discovery and development. The first part of the book reviews key principles and techniques used in the design and evaluation of drug candidates. The second part elucidates biological mechanisms of certain diseases, illuminating approaches to investigate and target these diseases. Comprising carefully selected reprints from the Encyclopedia as well as new contributions from leading scholars in the field, this book provides researchers in academia and industry with important information to aid in the development of novel agents to treat disease"--Provided by publisher. Part I: Drug discovery and development. The role of chemical biology in drug discovery -- Computational approaches to drug discovery and development -- Design and selection of small molecule inhibitors -- Lead optimization in drug discovery -- Pharmacokinetics of drug candidates -- ADME properties of drugs -- Drug transport in living systems -- Blood-brain barrier: considerations in drug development and delivery -- Pharmacokinetic considerations: methods and systems of controlled drug delivery -- Pharmaceuticals: natural products and natural product models -- Part II: Chemical biology to understand and target disease. The role of chemical biology in understanding and treating disease: are small molecule "correctors" the way of the future? -- Anxiety disorders -- Chronic obstructive pulmonary disease (COPD) -- Depression -- Osteoarthritis -- Human immunodeficiency virus (HIV) -- Allergy and asthma -- Schizophrenia -- Protein misfolding and disease -- Protein trafficking diseases -- Metabolic diseases -- Mitochondrial medicine -- Lysosomal disorders. edited by Natanya Civjan. Includes bibliographical references and index. Biochemistry Drug Discovery Drug Delivery Systems Biochemistry SCIENCE Life Sciences Biochemistry Biochemistry Biochemistry QP514.2 572 QV 745 Hoboken, N.J. : Wiley, 2012 (DLC) 2012012322 (OCoLC)749857596 9781118437674 1118437675 9781118435762 1118435761 9781118434505 1118434501 CL0500000213 Safari Books Online FB5E82B8-484A-4B92-BA65-C660A94D88E7 OverDrive, Inc. http://onlinelibrary.wiley.com/book/10.1002/9781118435762 http://onlinelibrary.wiley.com/book/10.1002/9781118435762 DG1 120907 20171114083050.0 ocn809370453 eng