04742cam a2200769Ii 4500 ocn809370453 OCoLC 20171114083050.0 m o d cr ||||||||||| 120907t20122012njua ob 001 0 eng 2012012322 9781118437674 (electronic bk.) 1118437675 (electronic bk.) 9781118435762 (electronic bk.) 1118435761 (electronic bk.) 9781118434505 (electronic bk.) 1118434501 (electronic bk.) 9781118101186 1118101189 9781283576055 1283576058 AU@ 000050060747 AU@ 000051432790 DEBBG BV041121688 DEBBG BV041829088 DEBSZ 396766102 DEBSZ 431131015 DKDLA 820120-katalog:000600184 NZ1 14976643 AU@ 000059228019 (OCoLC)809370453 (OCoLC)808771990 (OCoLC)811488646 (OCoLC)841331222 (OCoLC)961537416 (OCoLC)962595044 (OCoLC)966148373 CL0500000213 Safari Books Online FB5E82B8-484A-4B92-BA65-C660A94D88E7 OverDrive, Inc. http://www.overdrive.com DG1 eng rda pn DG1 OCLCQ N$T YDXCP E7B OCLCQ CDX OCLCQ CCO MHW UMI OCLCO COO DEBSZ TEFOD OCLCQ OCLCF OCLCQ MMU TEFOD EBLCP OCLCQ AZK DG1 OCLCO LOA OCLCA MAIN QP514.2 QV 745 SCI 007000 bisacsh 572 23 Chemical biology : approaches to drug discovery and development to targeting disease / edited by Natanya Civjan. [electronic resource] Hoboken, N.J. : Wiley, a John Wiley & Sons, Inc., Publication, [2012] ©2013 1 online resource (525 pages) : illustrations text txt rdacontent computer c rdamedia online resource cr rdacarrier data file rda Bibliography Includes bibliographical references and index. Part I: Drug discovery and development. The role of chemical biology in drug discovery -- Computational approaches to drug discovery and development -- Design and selection of small molecule inhibitors -- Lead optimization in drug discovery -- Pharmacokinetics of drug candidates -- ADME properties of drugs -- Drug transport in living systems -- Blood-brain barrier: considerations in drug development and delivery -- Pharmacokinetic considerations: methods and systems of controlled drug delivery -- Pharmaceuticals: natural products and natural product models -- Part II: Chemical biology to understand and target disease. The role of chemical biology in understanding and treating disease: are small molecule "correctors" the way of the future? -- Anxiety disorders -- Chronic obstructive pulmonary disease (COPD) -- Depression -- Osteoarthritis -- Human immunodeficiency virus (HIV) -- Allergy and asthma -- Schizophrenia -- Protein misfolding and disease -- Protein trafficking diseases -- Metabolic diseases -- Mitochondrial medicine -- Lysosomal disorders. "Based on the award-winning Wiley Encyclopedia of Chemical Biology published in 2008, this book explores the role of chemical biology in drug discovery and development. The first part of the book reviews key principles and techniques used in the design and evaluation of drug candidates. The second part elucidates biological mechanisms of certain diseases, illuminating approaches to investigate and target these diseases. Comprising carefully selected reprints from the Encyclopedia as well as new contributions from leading scholars in the field, this book provides researchers in academia and industry with important information to aid in the development of novel agents to treat disease"--Provided by publisher. Online resource; title from electronic title page (ebrary, viewed on February 24, 2015). Biochemistry. Drug Discovery. Drug Delivery Systems. Biochemistry. SCIENCE Life Sciences Biochemistry. bisacsh Biochemistry. fast (OCoLC)fst00831961 Biochemistry. local Electronic books. Electronic books. local Civjan, Natanya, editor. Print version: Chemical biology. Hoboken, N.J. : Wiley, 2012 9781118101186 (DLC) 2012012322 (OCoLC)749857596 http://onlinelibrary.wiley.com/book/10.1002/9781118435762 Wiley Online Library ddc BK 206148 206148