04250cam a2200649Ma 4500 ocn808867147 OCoLC 20171114084431.0 m o d cr |n||||||||| 120229s2012 nju ob 001 0 eng d 2012002908 9781118351918 (electronic bk.) 1118351916 (electronic bk.) 9781118351888 (electronic bk.) 1118351886 (electronic bk.) 9781118351901 (electronic bk.) 1118351908 (electronic bk.) 9780470577547 (Cloth) 0470577541 (Cloth) 9786613888525 EB00063407 Recorded Books AU@ 000050060705 DEBBG BV042795848 DKDLA 820120-katalog:000600169 NZ1 15915413 DEBBG BV043395019 (OCoLC)808867147 (OCoLC)808609679 (OCoLC)809539042 (OCoLC)864910874 (OCoLC)961633114 (OCoLC)962651029 (OCoLC)966109639 388852 MIL CDX eng pn CDX OCLCO IDEBK DG1 N$T E7B YDXCP OCLCQ UKDOC OCLCQ RECBK OCLCQ OCLCF OCLCQ COO OCLCQ DEBBG AZK LOA MAIN RA1242.D46 .R33 2012eb WA 671 MED 096000 bisacsh 615.9/5137 23 Radi, Zaher A. Comparative pathophysiology and toxicology of cyclooxygenases / Zaher A. Radi. [electronic resource] Hoboken, N.J. : Wiley, ©2012. 1 online resource text txt rdacontent computer c rdamedia online resource cr rdacarrier data file rda Bibliography Includes bibliographical references and index. The first thorough review of cyclooxygenase inhibitors, including their toxicity mechanisms and toxicopathological risks. Cyclooxygenases (COXs) are enzymes responsible for the formation of an important class of biological mediators called prostanoids. Prostanoids such as prostaglandins mediate inflammatory and anaphylactic reactions. For those suffering from inflammation and pain, the pharmacological inhibition of COXs, with non-steroidal anti-inflammatory drugs (NSAIDs), such as ibuprofen, can provide relief. Yet the use of NSAIDs can trigger toxicological effects as well, leading to potential health risks. Comparative Pathophysiology and Toxicology of Cyclooxygenases provides a comprehensive overview of how COX inhibitors affect various bodily systems, specifically the toxicity mechanisms triggered when the COX enzyme is inhibited. The book provides an introduction to the discovery of cyclooxygenases, their use as therapeutic agents, as well as an historical perspective. Shedding light on the differences in expression, pathophysiology, and toxicology of COX inhibitors across species, the book offers a systematic examination of the effects and pathophysiology of COX inhibitors and their mechanisms of toxicity, beginning with the GI tract. Subsequent chapters cover: The pathophysiology of COX inhibition on bone, tendon, and ligament healing, COX inhibitors and renal system pathophysiology and mechanisms of toxicity, The pathophysiologic role of COX inhibition in the ocular system, COX inhibition and the respiratory and cardiovascular systems. The book also sheds light on the latest research devoted to developing COX inhibitors with no adverse side-effects. The first book to offer a thorough comparative look at the toxicological effects of COX inhibitors throughout the body, this invaluable resource will help advance the research and development of safer and more effective COX drugs. Print version record. Cyclooxygenases Pathophysiology. Cyclooxygenases Toxicology. MEDICAL Toxicology. bisacsh Science. fast (OCoLC)fst01108176 Electronic books. Electronic books. local Print version: 9786613888525 (DLC) 2012002908 http://onlinelibrary.wiley.com/book/10.1002/9781118351918 Wiley Online Library ddc BK 206137 206137