05516cam a2200649Ia 4500 ocn807252111 OCoLC 20171114084258.0 m o d cr cnu---unuuu 120821s2012 gw ob 001 0 eng d 016099779 Uk 9783527664481 (electronic bk.) 3527664483 (electronic bk.) 3527333959 9783527664450 3527664459 9783527333950 9781283571432 (MyiLibrary) 1283571439 (MyiLibrary) 9783527664450 (electronic bk.) 9783527333950 AU@ 000050193180 CHBIS 010026781 CHVBK 306231409 DEBSZ 431210055 NZ1 15915034 DEBBG BV043394991 (OCoLC)807252111 (OCoLC)809775189 (OCoLC)811005776 N$T eng pn N$T YDXCP UKMGB OCLCQ COO OCLCQ CUS DG1 OCLCF MHW EBLCP CDX DEBSZ OCLCQ DEBBG MAIN QD400 (S SCI 013040 bisacsh 547.59 23 Bioactive heterocyclic compound classes : pharmaceuticals / edited by Jürgen Dinges and Clemens Lamberth. [electronic resource] Weinheim : Wiley-VCH ; Chichester : John Wiley [distributor], 2012. 1 online resource (xv, 356 pages) text txt rdacontent computer c rdamedia online resource cr rdacarrier Includes bibliographical references and index. This volume presents important pharmaceuticals. Each of the around 20 chapters covers in a concise manner one class of heterocycles, clearly structured as follows:* Structural formulas of most important examples (market products)* Short background of history or discovery* Typical syntheses of important examples* Mode of action* Characteristic biological activity* Structure-activity relationship* Additional chemistry information (e.g. further transformations, alternative syntheses, metabolic pathways, etc.)* References. A valuable one-stop reference source for researchers in academia and industr. Print version record. Heterocyclic compounds. Pharmaceutical chemistry. SCIENCE Chemistry Organic. bisacsh Heterocyclic compounds. fast (OCoLC)fst00955736 Pharmaceutical chemistry. fast (OCoLC)fst01060115 Electronic books. Lamberth, Clemens. Dinges, Jurgen. Print version: Bioactive heterocyclic compound classes. Weinheim : Wiley-VCH ; Chichester : John Wiley [distributor], 2012 9783527333950 (OCoLC)807249672 http://onlinelibrary.wiley.com/book/10.1002/9783527664450 Wiley Online Library 505-00/(S Introduction. The significance of heterocycles for pharmaceuticals and agrochemicals / Clemens Lamberth, Jürgen Dinges -- Neurological disorders. Tropane-based alkaloids as muscarinic antagonists for the treatment of asthma, obstructive pulmonary disease, and motion sickness / Michael L Schulte, Craig W Lindsley ; Morphinone-based opioid receptor agonist analgesics / Stephanie M Ng ; Barbituric acid-based GABA(A) receptor modulators for the treatment of sleep disorder and epilepsy and as anesthetics / Ingo Janser, Romy Janser ; Phenothiazine-based dopamine D antagonists for the treatment of schizophrenia / Cristiana A Zaharia ; Arylpiperazine-based 5-HT receptor partial agonists and 5-HT antagonists for the treatment of autism, depression, anxiety, psychosis, and schizophrenia / Irini Akritopoulou-Zanze ; Arylpiperidine-based dopamine D antagonists/5-HT antagonists for the treatment of autism, depression, schizophrenia, and bipolar disorder / Ying Wang ; Dibenzazepine-based sodium channel blockers for the treatment of neuropathic pain / Derek W Nelson -- Cardiovascular diseases. Dihydropyridine-based calcium channel blockers for the treatment of angina pectoris and hypertension / Milan Bruncko ; Tetrazole-based angiotensin II type 1 (AT) antagonists for the treatment of heart failure and congestive hypertension / Edward C Lawson, Brian C Shook, James C Lanter ; Thiazide-based diuretics for the treatment of hypertension and genitourinary disorders / Jürgen Dinges ; Tetrahydropyranone-based HMG-CoA reductase inhibitors for the treatment of arterial hypercholesterolemia / Hongyu Zhao -- Infectious diseases. Adenine-based reverse transcriptase inhibitors as anti-HIV agents / Alastair Donald ; Guanine-based nucleoside analogs as antiviral agents / Maurizio Franzini ; Penicillin and cephalosporin antibiotics / Michael Z Hoemann -- Oncology. Pyrimidine-based kinase inhibitors in cancer chemotherapy / Robert Mah ; Benzyl triazole-based aromatase inhibitors for the treatment of breast cancer / Dawn George, Stacy Van Epps -- Inflammation and gastrointestinal diseases. Acetonide-based glucocorticoids for the treatment of asthma, skin inflammation, and diseases of the eye / Kevin P Cusack, Vikram G Kalthod, Rajarathnam E Reddy, Sanjay R Chemburkar ; Benzimidazole-based H/K-ATPase inhibitors for the treatment of gastroesophageal reflux disease / Steve Swann -- Metabolic diseases. Thiazolidinedione-based insulin sensitizers: PPAR-γ agonists for the treatment of type 2 diabetes / Steven Richards -- Index. ddc BK 206120 206120