Lead optimization for medicinal chemists : pharmacokinetic properties of functional groups and organic compounds / Florencioa Zaragoza Dörwald. [electronic resource] Dörwald, Florencio Zaragoza. Pharmaceutical chemistry. RS403 615.19 Includes bibliographical references and index. Online resource; title from home page (viewed May 23, 2014). Small structural modifications can significantly affect the pharmacokinetic properties of drug candidates. This book, written by a medicinal chemist for medicinal chemists, is a comprehensive guide to the pharmacokinetic impact of functional groups, the pharmacokinetic optimization of drug leads, and an exhaustive collection of pharmacokinetic data, arranged according to the structure of the drug, not its target or indication. The historical origins of most drug classes and general aspects of modern drug discovery and development are also discussed. The index contains all the drug names and sy. 2012 Text 1 online resource (xvi, 605 pages) : http://onlinelibrary.wiley.com/book/10.1002/9783527645640 eng Lead optimization for medicinal chemists. Lead optimization for medicinal chemists.