04923cam a2200625Ma 4500 ocn802056669 OCoLC 20170612141630.0 m o d cr cn||||||||| 120713s2012 gw a ob 001 0 eng d E7B eng pn E7B OCLCO CDX DG1 YDXCP OCLCQ MMU OCLCF COO OCLCQ DEBBG AZK 961632173 962650062 9783527652969 (electronic bk.) 3527652965 (electronic bk.) 9783527652938 (e-book) 3527652930 (e-book) 9783527330591 AU@ 000050060714 DKDLA 820120-katalog:000599741 NZ1 14793349 DEBBG BV043394927 (OCoLC)802056669 (OCoLC)961632173 (OCoLC)962650062 RC119.7 .P37 2012eb 616.96061 23 MAIN Parasitic helminths : targets, screens, drugs and vaccines / edited by Conor R. Caffrey. Weinheim, Germany : Wiley-VCH, 2012. 1 online resource (xxiii, 516 pages :) : illustrations (some color). text txt rdacontent computer c rdamedia online resource cr rdacarrier data file rda Bibliography Drug discovery in infectious diseases ; v. 3 Includes bibliographical references and index. Part one: targets -- Ligand-gated ion channels as targets for anthelmintic drugs: past, current, and future perspectives -- How relevant is Caenorhabditis elegans as a model for the analysis of parasitic nematode biology? -- Integrating and mining helminth genomes to discover and prioritize novel therapeutic targets -- Recent progress in transcriptomics of key gastrointestinal nematodes of animals: fundamental research toward new intervention strategies -- Harnessing genomic technologies to explore the molecular biology of liver flukes-major implications for fundamental and applied research -- RNA interference: a potential discovery tool for therapeutic targets of parasitic nematodes -- RNA interference as a tool for drug discovery in parasitic flatworms -- Part two: screens -- Mechanism-based screening strategies for anthelmintic discovery -- Identification and profiling of nematicidal compounds in veterinary parasitology -- Quantitative high-content screening-based drug discovery against helmintic diseases -- Use of rodent models in the discovery of novel anthelmintics -- To kill a mocking worm: strategies to improve Caenorhabditis elegans as a model system for use in anthelmintic discovery -- Part three: drugs -- Anthelmintic drugs: tools and shortcuts for the long road from discovery to product -- Antinematodal drugs: modes of action and resistance: and worms will not come to thee (Shakespeare: Cymbeline: iv, ii) -- Drugs and targets to perturb the symbiosis of Wolbachia and filarial nematodes -- Promise of Bacillus thuringiensis crystal proteins as anthelmintics -- Monepantel: from discovery to mode of action -- Discovery, mode of action, and commercialization of derquantel -- Praziquantel: too good to be replaced? -- Drug discovery for trematodiases: challenges and progress -- Part four: vaccines -- Barefoot thru' the valley of darkness: preclinical development of a human hookworm vaccine -- Vaccines linked to chemotherapy: a new approach to control helminth infections -- Antifilarial vaccine development: present and future approaches -- Proteases as vaccines against gastrointestinal nematode parasites of sheep and cattle -- Schistosomiasis vaccines: new approaches to antigen discovery and promising new candidates -- Sm14 Schistosoma mansoni fatty acid-binding protein: molecular basis for an antihelminth vaccine -- Mechanisms of immune modulation by Fasciola hepatica: importance for vaccine development and for novel immunotherapeutics -- Prospects for immunoprophylaxis against Fasciola hepatica (liver fluke) -- Vaccines against cestode parasites. Helminths. Parasites. Parasitic diseases Treatment. Parasitic diseases Diagnosis. Helminths. fast (OCoLC)fst00954813 Parasites. fast (OCoLC)fst01053134 Parasitic diseases Diagnosis. fast (OCoLC)fst01053153 Parasitic diseases Treatment. fast (OCoLC)fst01053167 Electronic books. Caffrey, Conor R. Drug discovery in infectious diseases ; v. 3. http://onlinelibrary.wiley.com/book/10.1002/9783527652969 Wiley Online Library Coutts Information Services COUT 22738803 100.00 GBP ebrary EBRY ebr10575615 YBP Library Services YANK 8857278 YBP Library Services YANK 9571229 92 DG1 206059 206059