Avdeef, Alex. creator text bibliography Electronic books. nju 2012 monographic eng

electronic resource

1 online resource (xli, 698 pages) : illustrations BExplains how to perform and analyze the results of the latest physicochemical methods/b/ With this book as their guide, readers have access to all the current information needed to thoroughly investigate and accurately determine a compound's pharmaceutical properties and their effects on drug absorption. The book emphasizes oral absorption, explaining all the physicochemical methods used today to analyze drug candidates. Moreover, the author provides expert guidance to help readers analyze the results of their studies in order to select the most promising drug candidates./ This iSecond Edition/i has been thoroughly updated and revised, incorporating all the latest research findings, methods, and resources, including:/ ulli Descriptions and applications of new PAMPA models, drawing on more than thirty papers published by the author's research group/ /lili Two new chapters examining permeability and Caco-2/MDCK and permeability and the blood-brain barrier/ /lili Expanded information and methods to support pKa determination/ /lili New examples explaining the treatment of practically insoluble test compounds/ /lili Additional case studies demonstrating the use of the latest physicochemical techniques/ /lili New, revised, and expanded database tables throughout the book/ /li/ul Well over 200 drawings help readers better understand difficult concepts and provide a visual guide to complex procedures. In addition, over 800 references serve as a gateway to the primary literature in the field, facilitating further research into all the topics covered in the book./ This iSecond Edition/i is recommended as a reference for researchers in pharmaceutical R & D as well as in agrochemical, environmental, and other related areas of research. It is also recommended as a supplemental text for graduate courses in pharmaceutics. Introduction Transport model pKa determination -- Octanol-water partitioning -- Liposome-water partitioning -- Solubility -- Permeability -- Pampa -- Permeability Caco 2/MDCK -- Permeability blood brain barrier. Alex Avdeef. Includes bibliographical references and index. Drugs Metabolism Adsorption Drug development Drugs Design Pharmaceutical Preparations metabolism Administration, Oral Cell Membrane Permeability Pharmaceutical Preparations chemistry Structure-Activity Relationship Medical MEDICAL Drug Guides MEDICAL Nursing Pharmacology MEDICAL Pharmacology MEDICAL Pharmacy Adsorption Drug development Drugs Design Drugs Metabolism RS420 .A935 2012 615/.19 QV 38 9781118285961 1118285964 9781621982265 1621982262 1280589345 9781280589348 9781118286036 1118286030 EB00063291 Recorded Books http://onlinelibrary.wiley.com/book/10.1002/9781118286067 http://onlinelibrary.wiley.com/book/10.1002/9781118286067 CUS 120618 20171114092207.0 ocn795742377 eng