05072cam a2200865Ii 4500 ocn795742377 OCoLC 20171114092207.0 m o d cr cnu---unuuu 120618s2012 njua ob 001 0 eng d 9781118285961 (electronic bk.) 1118285964 (electronic bk.) 9781621982265 (electronic bk.) 1621982262 (electronic bk.) 1280589345 9781280589348 9781118286036 (electronic bk.) 1118286030 (electronic bk.) 9781118057452 (cloth) 1118057457 (cloth) 9781118286067 1118286065 EB00063291 Recorded Books AU@ 000049595454 DEBBG BV041905938 DEBBG BV042796569 NLGGC 343635054 NZ1 14791203 NZ1 15565388 NZ1 15921320 GBVCP 790199297 (OCoLC)795742377 (OCoLC)795808143 (OCoLC)817082051 (OCoLC)864909481 CUS eng rda pn CUS DG1 N$T OCLCQ KNOVL YDXCP ZCU KNOVL OCLCF KNOVL NLGGC IDEBK RECBK DEBBG OCLCQ TMC DG1 MAIN RS420 .A935 2012 QV 38 MED 023000 bisacsh MED 058170 bisacsh MED 071000 bisacsh MED 072000 bisacsh 615/.19 23 Avdeef, Alex. Absorption and drug development : solubility, permeability, and charge state / Alex Avdeef. [electronic resource] Hoboken, N.J. : John Wiley & Sons, ©2012. 1 online resource (xli, 698 pages) : illustrations text txt rdacontent computer c rdamedia online resource cr rdacarrier Includes bibliographical references and index. Introduction Transport model pKa determination -- Octanol-water partitioning -- Liposome-water partitioning -- Solubility -- Permeability -- Pampa -- Permeability Caco 2/MDCK -- Permeability blood brain barrier. BExplains how to perform and analyze the results of the latest physicochemical methods/b/ With this book as their guide, readers have access to all the current information needed to thoroughly investigate and accurately determine a compound's pharmaceutical properties and their effects on drug absorption. The book emphasizes oral absorption, explaining all the physicochemical methods used today to analyze drug candidates. Moreover, the author provides expert guidance to help readers analyze the results of their studies in order to select the most promising drug candidates./ This iSecond Edition/i has been thoroughly updated and revised, incorporating all the latest research findings, methods, and resources, including:/ ulli Descriptions and applications of new PAMPA models, drawing on more than thirty papers published by the author's research group/ /lili Two new chapters examining permeability and Caco-2/MDCK and permeability and the blood-brain barrier/ /lili Expanded information and methods to support pKa determination/ /lili New examples explaining the treatment of practically insoluble test compounds/ /lili Additional case studies demonstrating the use of the latest physicochemical techniques/ /lili New, revised, and expanded database tables throughout the book/ /li/ul Well over 200 drawings help readers better understand difficult concepts and provide a visual guide to complex procedures. In addition, over 800 references serve as a gateway to the primary literature in the field, facilitating further research into all the topics covered in the book./ This iSecond Edition/i is recommended as a reference for researchers in pharmaceutical R & D as well as in agrochemical, environmental, and other related areas of research. It is also recommended as a supplemental text for graduate courses in pharmaceutics. Print version record. Drugs Metabolism. Adsorption. Drug development. Drugs Design. Pharmaceutical Preparations metabolism. Administration, Oral. Cell Membrane Permeability. Pharmaceutical Preparations chemistry. Structure-Activity Relationship. Medical. MEDICAL Drug Guides. bisacsh MEDICAL Nursing Pharmacology. bisacsh MEDICAL Pharmacology. bisacsh MEDICAL Pharmacy. bisacsh Adsorption. fast (OCoLC)fst00797186 Drug development. fast (OCoLC)fst00898670 Drugs Design. fast (OCoLC)fst00898790 Drugs Metabolism. fast (OCoLC)fst00898845 Electronic books. http://onlinelibrary.wiley.com/book/10.1002/9781118286067 Wiley Online Library ddc BK 205962 205962