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  <titleInfo>
    <title>Telomerases : chemistry, biology and clinical applications</title>
  </titleInfo>
  <name type="personal">
    <namePart>Lue, Neal F.</namePart>
    <namePart type="date">1962-</namePart>
  </name>
  <name type="personal">
    <namePart>Autexier, Chantal</namePart>
    <namePart type="date">1963-</namePart>
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  <genre authority="">Electronic books.</genre>
  <genre authority="local">Electronic books.</genre>
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    <place>
      <placeTerm type="text">Hoboken</placeTerm>
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    <publisher>John Wiley &amp; Sons</publisher>
    <dateIssued>2012</dateIssued>
    <issuance>monographic</issuance>
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  <language>
    <languageTerm authority="iso639-2b" type="code">eng</languageTerm>
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    <extent>1 online resource (x, [16], 308 pages) : illustrations (some color)</extent>
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  <abstract>"This book is a comprehensive and up-to-date review and evaluation of the contemporary status of telomerase research. Chapters in this volume cover the basic structure, mechanisms, and diversity of the essential and regulatory subunits of telomerase. Other topics include telomerase biogenesis, transcriptional and post-translational regulation, off-telomere functions of telomerase and the role of telomerase in cellular senescence, aging and cancer. Its relationship to retrotransposons, a class of mobile genetic elements that shares similarities with telomerase and serves as telomeres in selected organisms, are also reviewed"--Provided by publisher.</abstract>
  <tableOfContents>The telomerase complex : an overview / Johanna Mancini and Chantal Autexier -- Telomerase RNA : structure, function, and molecular mechanisms / Yehudi Tzfati and Julian J.-L. Chen -- TERT structure, function, and molecular mechanisms / Emmanuel Skordalakes and Neal F. Lue -- Telomerase biogenesis : RNA Processing, trafficking and protein Interactions / Tara Beattie and Pascal Chartrand -- Transcriptional regulation of human telomerase / Antonella Farsetti and Yu-Sheng Cong -- Telomerase regulation and telomere length homeostasis / Joachim Lingner and David Shore -- Telomere structure in telomerase regulation / Momchil D. Vodenicharov and Raymund J. Wellinger -- Off-telomere functions of telomerase / Kenkichi Masutomi and William C. Hahn -- Murine Models of Dysfunctional Telomeres and Telomerase / Yie Liu and Lea Harrington -- Cellular senescence, telomerase, and cancer in human cells / Phillip G. Smiraldo [and others] -- Telomerase, retrotransposons, and evolution / Irina R. Arkhipova.</tableOfContents>
  <note type="statement of responsibility">edited by Neal F. Lue and Chantal Autexier.</note>
  <note>Includes bibliographical references and index.</note>
  <subject authority="lcsh">
    <topic>Telomerase</topic>
    <topic>Physiology</topic>
  </subject>
  <subject authority="lcsh">
    <topic>Telomerase</topic>
    <topic>Metabolism</topic>
  </subject>
  <subject authority="lcsh">
    <topic>Telomerase</topic>
    <topic>Genetics</topic>
  </subject>
  <subject authority="lcsh">
    <topic>Geriatrics</topic>
  </subject>
  <subject>
    <topic>Natural history</topic>
  </subject>
  <subject>
    <topic>Science</topic>
  </subject>
  <subject authority="bisacsh">
    <topic>SCIENCE</topic>
    <topic>Life Sciences</topic>
    <topic>Molecular Biology</topic>
  </subject>
  <subject authority="bisacsh">
    <topic>SCIENCE</topic>
    <topic>Life Sciences</topic>
    <topic>Genetics &amp; Genomics</topic>
  </subject>
  <subject authority="fast">
    <topic>Science</topic>
  </subject>
  <subject authority="mesh">
    <topic>Telomerase</topic>
  </subject>
  <classification authority="lcc">QP606 .T44 T45 2012</classification>
  <classification authority="ddc">572.7 572.8 572.86</classification>
  <classification authority="nlm">QU 56</classification>
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      <publisher>Hoboken : John Wiley &amp; Sons, ©2012</publisher>
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  <identifier type="isbn">9781118268667</identifier>
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  <identifier type="uri">http://onlinelibrary.wiley.com/book/10.1002/9781118268667</identifier>
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