Protein-ligand interactions / edited by Holger Gohlke. [electronic resource] Gohlke, Holger. Proteins. Ligands (Biochemistry) Ligand binding (Biochemistry) Drugs Structure-activity relationships. QP551 .P69598 2012 615.19 23 Includes bibliographical references and index. Print version record. Innovative and forward-looking, this volume focuses on recent achievements in this rapidly progressing field and looks at future potential for development. The first part provides a basic understanding of the factors governing protein-ligand interaction, followed by a comparison of the four key experimental methods (calorimetry, surface plasmon resonance, NMR and X-ray crystallography) used in generating interaction data. The second half of the book is devoted to in-silico methods of modeling and predicting molecular recognition and binding. Here, as elsewhere in the book, emphasis is placed on novel approaches and recent improvements to established methods. The final part looks at unresolved challenges, and the strategies to address them. Weinheim : Wiley-VCH, ©2012. ©2012. 2012 Text 1 online resource (xx, 339 pages) : http://onlinelibrary.wiley.com/book/10.1002/9783527645947 eng Methods and principles in medicinal chemistry ; v. 53 Methods and principles in medicinal chemistry ; v. 53. Protein-ligand interactions. Protein-ligand interactions.