04702cam a2200697 a 4500 ocn785722063 OCoLC 20171114105345.0 m o d cr un|---uuuuu 120411s2012 enk ob 001 0 eng 2012015088 9781118348994 (ePub) 1118348990 (ePub) 9781118348963 (Adobe PDF) 1118348966 (Adobe PDF) 9781118348987 (MobiPocket) 1118348982 (MobiPocket) 9781118348970 (electronic bk.) 1118348974 (electronic bk.) 9781119995951 (cloth) 1119995957 (cloth) 9781119995944 (pbk.) 1119995949 (pbk.) AU@ 000049032391 DEBBG BV042795159 DEBSZ 397319665 DEBSZ 425885321 NZ1 15916053 AU@ 000059227966 (OCoLC)785722063 (OCoLC)811865406 (OCoLC)844915169 DLC eng pn DLC YDX EBLCP N$T UIU MERUC DG1 YDXCP E7B UBY UWO CDX DEBSZ IUL OCLCF COO OCLCQ pcc MAIN QP601 MED 008000 bisacsh 612/.0151 23 Bugg, Tim. Introduction to enzyme and coenzyme chemistry / T.D.H. Bugg. [electronic resource] 3rd ed. Chichester, West Sussex : Wiley, 2012. 1 online resource. text txt rdacontent computer c rdamedia online resource cr rdacarrier Includes bibliographical references and index. 2.6 The folded tertiary structure of proteins2.7 Enzyme structure and function; 2.8 Metallo-enzymes; 2.9 Membrane-associated enzymes; 2.10 Glycoproteins; 3 Enzymes Are Wonderful Catalysts; 3.1 Introduction; 3.2 A thermodynamic model of catalysis; 3.3 Proximity effects; 3.4 The importance of transition state stabilisation; 3.5 Acid/base catalysis in enzymatic reactions; 3.6 Nucleophilic catalysis in enzymatic reactions; 3.7 The use of strain energy in enzyme catalysis; 3.8 Desolvation of substrate and active site nucleophiles; 3.9 Catalytic perfection. 3.10 The involvement of protein dynamics in enzyme catalysis4 Methods for Studying Enzymatic Reactions; 4.1 Introduction; 4.2 Enzyme purification; 4.3 Enzyme kinetics; 4.4 The stereochemical course of an enzymatic reaction; 4.5 The existence of intermediates in enzymatic reactions; Direct observation; Trapping; Chemical inference; Isotope exchange; 4.6 Analysis of transition states in enzymatic reactions; 4.7 Determination of active site catalytic groups; 5 Hydrolytic and Group Transfer Enzymes; 5.1 Introduction; 5.2 The peptidases; The Serine Proteases; The Cysteine Proteases. The Metallo-proteasesThe Aspartyl Proteases; CASE STUDY: HIV-1 protease; 5.3 Esterases and lipases; 5.4 Acyl transfer reactions in biosynthesis (coenzyme A); 5.5 Enzymatic phosphoryl transfer reactions; 5.6 Adenosine 5'-triphosphate (ATP); 5.7 Enzymatic glycosyl transfer reactions; 5.8 Methyl group transfer: use of S-adenosyl methionine and tetrahydrofolate coenzymes for one-carbon transfers; 6 Enzymatic Redox Chemistry; 6.1 Introduction; 6.2 Nicotinamide adenine dinucleotide-dependent dehydrogenases; 6.3 Flavin-dependent dehydrogenases and oxidases; 6.4 Flavin-dependent mono-oxygenases. Looking at enzymes from an organic chemistry perspective, this updated reference includes information on recent advances in our understanding of enzyme action; topical examples to illustrate key points; two-color figures of the active sites of enzymes discussed in the text to illustrate the interplay between enzyme structure and function; and end-of-chapter problems to allow readers to check their understanding of the material. This concise but comprehensive guide is essential for undergraduate and postgraduate students of organic, bio-organic, and medicinal chemistry, chemical biology, bioche. Print version record and CIP data provided by publisher. Enzymes. Coenzymes. MEDICAL Biochemistry. bisacsh Coenzymes. fast (OCoLC)fst00866295 Enzymes. fast (OCoLC)fst00913605 Electronic books. Print version: Bugg, Tim. Introduction to enzyme and coenzyme chemistry. 3rd ed. Hoboken, NJ : Wiley, 2012 9781119995951 (DLC) 2012008853 http://onlinelibrary.wiley.com/book/10.1002/9781118348970 Wiley Online Library ddc BK 205811 205811