05189cam a2200805 a 4500 ocn780063970 OCoLC 20171115085534.0 m o d cr ||||||||||| 120312s2012 enk ob 001 0 eng 2012010703 9781119940678 (ePub) 1119940672 (ePub) 9781119940678 (Adobe PDF) 1119940672 (Adobe PDF) 9781119940999 (MobiPocket) 1119940990 (MobiPocket) 9781119940685 (electronic bk.) 1119940680 (electronic bk.) 1118231783 (pbk.) 9781118231784 (pbk.) 0470974257 9780470974254 9781280599255 (MyiLibrary) 1280599251 (MyiLibrary) 9781118231784 (pbk.) AU@ 000048818889 DEBBG BV040490338 DEBBG BV040886820 DEBSZ 431109605 DEBSZ 449291766 DKDLA 820120-katalog:000600868 NLGGC 382504801 NZ1 14693350 (OCoLC)780063970 (OCoLC)785732724 (OCoLC)794488180 (OCoLC)805656731 (OCoLC)808597210 (OCoLC)961495932 (OCoLC)962649311 (OCoLC)966107916 10.1002/9781119940685 Wiley InterScience http://www3.interscience.wiley.com DLC eng pn DLC EBLCP CUS YDXCP N$T DG1 E7B CDX Q2U MYG COO OCLCF DEBBG NLGGC DEBSZ MHW OTZ GPM UKDOC OCLCQ OCLCO OCLCQ AZK LOA OCLCO OCLCA pcc MAIN RA1199.4.A46 R46 2012 QT 36 SCI 049000 bisacsh 572.8 23 Replacing animal models : a practical guide to creating and using culture-based biomimetic alternatives / edited by Jamie Davies. [electronic resource] Chichester, West Sussex, UK ; Hoboken, NJ : John Wiley - Blackwell, 2012. 1 online resource. text txt rdacontent computer c rdamedia online resource cr rdacarrier data file rda Bibliography Includes index. Includes bibliographical references and index. Potential advantages of using biomimetic alternatives / Jamie Davies -- Overview of biomimetic alternatives / Jamie Davies -- Pancreatic islands / Eli C. Lewis -- Endometrial organoid culture / Merja Blauer -- Modelling lymphatic and blood capillary patterning / Francoise Bruyere [and others] -- Precision-cut lung slices (PCLS) / Christian Martin and Stefan Uhlig -- Human colon tissue in organ culture / Michael K. Dame and James Varani -- Fetal organs culture / Jamie Davies -- Design of a mechanical loading device to culture intact bovine spinal motion segments under multiaxial motion / Jochen Walser, Stephen John Ferguson, and Benjamin Gantenbein-Ritter -- Magnetic assembly of tissue surrogates / Chien-Yu Fu and Hwan-You Chang -- Assembly of renal tissues by cellular self-organization / Mathieu Unbekandt -- Hierarchical screening of pathways: using cell and organ cultures to reduce use of transgenic mice / Guangping Tai and Jamie Davies -- Lung organoid culture to study response to viruses / Wenxin Wu, J. Leland Booth, and Jordan P. Metcalf -- Organ-cultured human skin for the study of epithelial cell invasion of stroma / James Varani -- Organotypic mandibular cultures for the study of inflammatory bone pathology / Alastair J. Sloan, Sarah Y. Taylor, and Emma L. Smith -- Three-dimensional, high-density and tissue engineered culture models of articular cartilage / Ali Mobasheri [and others] -- Concluding remarks / Jamie Davies. "The book is neither political nor polemical: it is technical, illustrating by example how alternatives can be developed and used and providing useful advice on developing others. After looking at the reasons for and potential benefits of alternatives to animal experiments, the book covers a range of methods and examples emphasising the design considerations that went into each system. The chapters also include 'case studies' that illustrate the ways in which culture models can be used to answer a range of important biological questions of direct relevance to human development, physiology, disease and healing."-- Provided by publisher. Print version record and CIP data provided by publisher. Alternative toxicity testing. Animal Testing Alternatives. Biomimetics methods. Models, Animal. SCIENCE Life Sciences Molecular Biology. bisacsh Alternative toxicity testing. fast (OCoLC)fst00806188 Electronic books. Electronic books. local Davies, Jamie A. Print version: Replacing animal models. Chichester, West Sussex : John Wiley & Sons, 2012 9781118231784 (DLC) 2012009483 http://onlinelibrary.wiley.com/book/10.1002/9781119940685 Wiley Online Library ddc BK 205712 205712