Kontermann, Roland 1961- editor. text bibliography Electronic books. gw 2012 2012 monographic eng

electronic resource

1 online resource (374 pages) : illustrations (some color) For this ready reference, the internationally renowned authority in the field, Roland Kontermann, has assembled a team of outstanding contributors from industry and academia to convey the worldwide knowledge on modifying therapeutic proteins in order to optimize their pharmacological potential. The result is a comprehensive work covering all approaches and aspects of the topic in one handy volume, making this indispensable reading for companies and research institutions working on the development of biopharmaceuticals. General information -- Half-life modulating strategies : an introduction -- Pharmacokinetics and half-life of protein therapeutics -- Half-life extension through chemical and post-translational modifications -- Half-life extension through PEGylation -- Half-life extension of therapeutic proteins via genetic fusion to recombinant PEG mimetics -- Half-life extension through O-glycosylation -- Polysialic acid and polysialylation to modulate antibody pharmacokinetics -- Half-life extension through HESylation -- Half-life modulation involving recycling by the neonatal Fc receptor -- The biology of the neonatal Fc receptor (FcRn) -- half-life extension by fusion to the Fc region -- Monomeric Fc fusion technology: an approach to create long-lasting clotting factors -- The diverse roles of FcRn: implications for antibody engineering -- Half-life extension by fusion to recombinant albumin -- AlbudAb technology platform: versatile albumin binding domains for the development of therapeutics with tunable half-lives -- Half-life extension by binding to albumin through an albumin binding domain -- Half-life extension by binding to albumin through small molecules -- Half-life extension with pharmaceutical formulations -- Half-life extension with pharmaceutical formulations: liposomes -- Half-life extension with pharmaceutical formulations: nanoparticles by the miniemulsion process. edited by Roland Kontermann. Includes bibliographical references and index. Protein drugs Design Proteins Therapeutic use Proteins pharmacokinetics Half-Life MEDICAL Pharmacology Protein drugs Design Proteins Therapeutic use RS431.P75 615.3 QU 55 Weinheim, Germany : Wiley-VCH, ©2011 (DLC) 2012540834 (OCoLC)768072878 9783527644827 3527644822 9783527644797 3527644792 9783527644780 3527644784 9783527644803 3527644806 128345422X 9781283454223 10.1002/9783527644827 Wiley InterScience http://onlinelibrary.wiley.com/book/10.1002/9783527644827 http://onlinelibrary.wiley.com/book/10.1002/9783527644827 DG1 120309 20171115090956.0 ocn779616898 eng