06694cam a2200853Ia 4500 ocn779410061 OCoLC 20171115091807.0 m o d cr cnu---unuuu 120306s2012 njua ob 001 0 eng d 9781118098141 1118098145 9781118098127 1118098129 9781280589324 (MyiLibrary) 1280589329 (MyiLibrary) 9781118098134 (electronic bk.) 1118098137 (electronic bk.) 9780470590904 0470590904 EB00062625 Recorded Books AU@ 000049014066 DEBBG BV042794916 DEBBG BV043394309 DKDLA 820120-katalog:000600378 NLGGC 340803193 NZ1 14976855 ZWZ 17893285X (OCoLC)779410061 (OCoLC)784124194 (OCoLC)811493986 (OCoLC)839336010 (OCoLC)860514925 (OCoLC)898985525 (OCoLC)961529870 (OCoLC)962708756 10.1002/9781118098141 Wiley InterScience http://www3.interscience.wiley.com N$T eng pn N$T UIU DG1 YDXCP CDX IUL OCLCQ MYG E7B COO NLGGC OCLCF RECBK NLE MHW IDEBK OCLCQ D6H OCLCQ AZK MAIN RM301.25 .P65 2012eb QV 744 MED 023000 bisacsh MED 058170 bisacsh MED 071000 bisacsh MED 072000 bisacsh 615.19 23 44.42 bcl Polypharmacology in drug discovery / edited by Jens-Uwe Peters. [electronic resource] Hoboken, N.J. : Wiley, ©2012. 1 online resource (xxiii, 510 pages) : illustrations text txt rdacontent computer c rdamedia online resource cr rdacarrier data file rda Bibliography Includes bibliographical references and index. Frontmatter -- Color Plates -- Introduction: The Case for Polypharmacology / Andrew L Hopkins -- Polypharmacology: A Safety Concern in Drug Discovery. The Relevance of Off-Target Polypharmacology / Bruce D Car -- Screening for Safety-Relevant Off-Target Activities / Laszlo Urban, Steven Whitebread, Jacques Hamon, Dmitri Mikhailov, Kamal Azzaoui -- Pharmacological Promiscuity and Molecular Properties / Jens-Uwe Peters -- Kinases as Antitargets in Genotoxicity / Stephan Kirchner -- Activity at Cardiovascular Ion Channels: A Key Issue for Drug Discovery / Ian M Bell, Mark T Bilodeau, Armando A Lagrutta -- Prediction of Side Effects Based on Fingerprint Profiling and Data Mining / Jacques Migeon -- Polypharmacology: An Opportunity for Drug Discovery. Polypharmacological Drugs: ₃Magic Shotguns₄ for Psychiatric Diseases / Wesley K Kroeze, Bryan L Roth -- Polypharmacological Kinase Inhibitors: New Hopes for Cancer Therapy / Annalisa Petrelli -- Polypharmacology as an Emerging Trend in Antibacterial Discovery / Lynn L Silver -- A ₃Magic Shotgun₄ Perspective on Anticonvulsant Mechanisms / Matt T Bianchi, Kathy Chuang -- Selective Optimization of Side Activities (SOSA): A Promising way for Drug Discovery / Thierry Langer, Camille-Georges Wermuth -- Selected Approaches to Polypharmacological Drug Discovery. Selective Multitargeted Drugs / Richard Morphy -- Computational Multitarget Drug Discovery / Jeremy A Horst, Adrian Laurenzi, Brady Bernard, Ram Samudrala -- Behavior-Based Screening as an Approach to Polypharmacological Ligands / Dani Brunner, Vadim Alexandrov, Barbara Caldarone, Taleen Hanania, David Lowe, Jeff Schneider, Jayaraman Chandrasekhar -- Multicomponent Therapeutics / Alexis A Borisy, Grant R Zimmermann, Joseph Leh̀r -- Case Studies. Discovery of Sunitinib as a Multitarget Treatment of Cancer / Catherine Delbaldo, Camelia Colichi, Marie-Paule Sablin, Chantal Dreyer, Bertrand Billemont, Sandrine Faivre, Eric Raymond -- Antipsychotics / Claus Riemer -- Triple-Uptake Inhibitors (Broad-Spectrum Antidepressants) / Phil Skolnick -- Therapeutic Potential of Small Molecules Modulating the Cyclooxygenase₆5-Lipoxygenase Pathway / Wolfgang Albrecht, Stefan Laufer -- Drug Research Leading to Imatinib and beyond to Nilotinib / Paul W Manley, Jorg Zimmermann -- Towards Antimalarial Hybrid Drugs / Bernard Meunier -- Multitargeted Drugs for Treatment of Alzheimer's Disease / Andrea Cavalli, Maria Laura Bolognesi -- Carbonic Anhydrases: Off Targets, Add-On Activities, or Emerging Novel Targets? / Claudiu T Supuran -- Index. "Covers the two-sided nature of polypharmacology--its contribution to adverse drug reactions and its benefit in certain therapeutic drug classes. Addresses the important topic of polypharmacology in drug discovery, a subject that has not been thoroughly covered outside of scattered journal articles. Overviews state-of-the-art approaches and developments to help readers understand concepts and issues related to polypharmacology."-- Provided by publisher. "An essential outline of the main facets of polypharmacology in drug discovery research. Extending drug discovery opportunities beyond the "one drug, one target" philosophy, a polypharmacological approach to the treatment of complex diseases is emerging as a hot topic in both industry and academic research. Polypharmacology in Drug Discovery presents an overview of the various facets of polypharmacology and how it can be applied as an innovative concept for developing medicines for treating bacterial infections, epilepsy, cancer, psychiatric disorders, and more."-- Provided by publisher. Print version record. Drug development. Drugs Toxicology. Pharmacology. Medical. MEDICAL Drug Guides. bisacsh MEDICAL Nursing Pharmacology. bisacsh MEDICAL Pharmacology. bisacsh MEDICAL Pharmacy. bisacsh Drug development. fast (OCoLC)fst00898670 Drugs Toxicology. fast (OCoLC)fst00898958 Pharmacology. fast (OCoLC)fst01060259 Drug Discovery. Drug Toxicity. Pharmaceutical Preparations chemistry. Electronic books. Peters, Jens-Uwe. Print version: Polypharmacology in drug discovery. Hoboken, N.J. : Wiley, ©2011 9780470590904 (DLC) 2011052324 (OCoLC)714728070 http://onlinelibrary.wiley.com/book/10.1002/9781118098141 Wiley Online Library ddc BK 205678 205678