06564cam a2200841Ka 4500 ocn746324268 OCoLC 20171116113103.0 m o d cr cn||||||||| 110811s2011 nju ob 001 0 eng d 2011008300 9781118092804 (electronic bk.) 1118092805 (electronic bk.) 9781118092835 (electronic bk.) 111809283X (electronic bk.) 1283239906 9781283239905 9780470596685 0470596686 9781118092811 9786613239907 AU@ 000047980772 AU@ 000053283782 DKDLA 820120-katalog:000582692 NZ1 14691830 DEBBG BV043393375 (OCoLC)746324268 (OCoLC)748534091 (OCoLC)751970372 (OCoLC)757395717 (OCoLC)759006616 (OCoLC)816859643 (OCoLC)961631470 (OCoLC)962609688 (OCoLC)966196074 10.1002/9781118092804 Wiley InterScience http://www3.interscience.wiley.com DG1 eng pn DG1 IDEBK OCLCQ YDXCP N$T CDX E7B OCLCQ OCLCF OCLCA UKDOC OCLCQ NLGGC EBLCP OCLCQ DEBBG D6H AZK LOA OCLCO OCLCA MAIN RS400 .M438 2011 QV 185 MED 023000 bisacsh MED 058170 bisacsh MED 071000 bisacsh MED 072000 bisacsh PN bicssc 615/.19 22 Medicinal chemistry of nucleic acids / edited by Li He Zhang, Zhen Xi, Jyoti Chattopadhyaya. [electronic resource] Hoboken, N.J. : John Wiley & Sons, ©2011. 1 online resource. text txt rdacontent computer c rdamedia online resource cr rdacarrier Wiley series in drug discovery and development Includes bibliographical references and index. Frontmatter -- Color Plates -- Recent Advances in Carbocyclic Nucleosides: Synthesis and Biological Activity / Jianing Wang, Ravindra K Rawal, Chung K Chu -- Structures and Functions of Nucleic Acids Modified With S, Se, and Te and Complexed with Small Molecules / Wen Zhang, Jia Sheng, Zhen Huang -- Unraveling of the NAD Cyclizing and Calcium Signaling Functions of Human CD38 / Hon Cheung Lee -- DNA and RNA Binding Small Molecules / Shibo Li, Zhen Xi -- G-Quadruplex DNA and its Ligands in Anticancer Therapy / Zhi-Shu Huang, Jia-Heng Tan, Tian-Miao Ou, Ding Li, Lian-Quan Gu -- Molecular Modeling in Nucleic Acid-Targeted Drug Design / Lidan Sun, Hongwei Jin, Liangren Zhang, Lihe Zhang -- Structure of 10₆23 DNAzyme in Complex with the Target RNA --A Progress Report on the Mechanism of RNA Cleavage by DNA Enzyme / Oleksandr Plashkevych, Jyoti Chattopadhyaya -- Labeling Oligonucleotides toward the Biomedical Probe / Il Joon Lee, Byeang Hyean Kim -- Locked Nucleic Acid Oligonucleotides toward Clinical Applications / Rakesh N Veedu, Jesper Wengel -- The Pharmacokinetics Research of Nucleic Acid Drugs / Shengqi Wang, Dandan Lu, Qingqing Wang, Haifeng Song, Chan Gao, Caihong Liu, Ying Wang -- Inducible RNAi and Drug Target Validation / Wei Xiong, Jing Zhao, Yufan Zhang, Jinxi Wang, Yong-Xiang Zheng, Qiu-Chen He, Li-He Zhang, De-Min Zhou -- siRNA: The Specificity and off-Target Effects / Quan Du, Huang Huang, Zicai Liang -- Index -- Wiley Series in Drug Discovery and Development. Recent advances in carbocyclic nucleosides : synthesis and biological activity / Jianing Wang, Ravindra K. Rawal, and Chung K. Chu -- Structures and functions of nucleic acids modified with S, Se, and Teand complexed with small molecules / Wen Zhang, Jia Sheng, and Zhen Huang -- Unraveling of the NAD cyclizing and calcium signaling functions of human CD38 / Hon Cheung Lee -- DNA and RNA binding small molecules / Shibo Li and Zhen Xi -- G-quadruplex DNA and its ligands in anticancer therapy / Zhi-shu Huang [and others] -- Molecular modeling in nucleic acid targeted drug design / Lidan Sun [and others] -- Structure of 10-23 DNAzyme in complex with the target RNA in silico : a progress report on the mechanism of RNA cleavage by DNA enzyme / Oleksandr Plashkevych and Jyoti Chattopadhyaya -- Labeling oligonucleotides towards the biomedical probe / Il Joon Lee and Byeang Hyean Kim -- Locked nucleic acid oligonucleotides towards clinical application / Rakesh N. Veedu and Jesper Wengel -- The pharmacokinetics researches of nucleic acid drugs / Shengqi Wang -- Inducible RNAi and drug target validation / Wei Xiong [and others] -- SiRNA : the specificity and off-target effects -- Quan Du, Huang Huang, Zicai Liang. Covering all areas of the medicinal chemistry and therapeutic applications of nucleic acids, this book provides up-to-date coverage of the broad area of nucleic acid chemistry and biology. The book lays out the basic principles of medicinal chemistry of nucleic acids before focusing on the development and application of modified nucleosides and nucleotides in medicinal chemistry. Cutting-edge subjects for drug discovery like antisense, RNAi, and siRNA are also discussed, and help the target audience of chemists, pharmaceutical researchers, and academics understand the use of nucleic acid drugs to treat diseases. Print version record. Pharmaceutical chemistry. Nucleic acids Therapeutic use. MEDICAL Drug Guides. bisacsh MEDICAL Nursing Pharmacology. bisacsh MEDICAL Pharmacology. bisacsh MEDICAL Pharmacy. bisacsh Nucleic acids Therapeutic use. fast (OCoLC)fst01041085 Pharmaceutical chemistry. fast (OCoLC)fst01060115 Nucleic Acids pharmacology. Nucleic Acids therapeutic use. Electronic books. Electronic resource. Electronic books. local Zhang, Li He. Xi, Zhen. Chattopadhyaya, Jyoti. Wiley InterScience (Online service) Print version: Medicinal chemistry of nucleic acids. Hoboken, N.J. : John Wiley & Sons, Inc., ©2011 9780470596685 (DLC) 2011008300 (OCoLC)705260904 Wiley series in drug discovery and development. http://onlinelibrary.wiley.com/book/10.1002/9781118092804 Wiley Online Library ddc BK 205198 205198