Medicinal chemistry of nucleic acids / edited by Li He Zhang, Zhen Xi, Jyoti Chattopadhyaya. [electronic resource] Zhang, Li He. Xi, Zhen. Chattopadhyaya, Jyoti. Wiley InterScience (Online service) Pharmaceutical chemistry. Nucleic acids Therapeutic use. Nucleic Acids pharmacology. Nucleic Acids therapeutic use. RS400 .M438 2011 615/.19 22 Includes bibliographical references and index. Print version record. Covering all areas of the medicinal chemistry and therapeutic applications of nucleic acids, this book provides up-to-date coverage of the broad area of nucleic acid chemistry and biology. The book lays out the basic principles of medicinal chemistry of nucleic acids before focusing on the development and application of modified nucleosides and nucleotides in medicinal chemistry. Cutting-edge subjects for drug discovery like antisense, RNAi, and siRNA are also discussed, and help the target audience of chemists, pharmaceutical researchers, and academics understand the use of nucleic acid drugs to treat diseases. Hoboken, N.J. : John Wiley & Sons, ©2011. ©2011. 2011 Text 1 online resource. http://onlinelibrary.wiley.com/book/10.1002/9781118092804 eng Wiley series in drug discovery and development Wiley series in drug discovery and development. Medicinal chemistry of nucleic acids. Medicinal chemistry of nucleic acids.