Boverhof, Darrell R. Gollapudi, B. Bhaskar. text bibliography Electronic books. Electronic resource. Electronic books. nju Hoboken, N.J John Wiley & Sons ©2011 2011 monographic eng

electronic resource

1 online resource (xiii, 377 pages) : illustrations "This book provides a timely overview of toxicogenomics, with special emphasis on the practical applications of this technology to the risk assessment process. Introductory sections are followed by a series of chapters highlighting practical and systematic applications of toxicogenomics in informing the risk assessment process - including the areas of mutagenicity, carcinogenicity, endocrine toxicity, organ-specific toxicity, population monitoring, and ecotoxicology. The book concludes with approaches for the integration of this technology in safety evaluation studies, and an outlook on how toxicogenomics and complementary technologies can reframe the current risk assessment paradigm"--Provided by publisher. Toxicology, "omics" technologies, and toxicogenomics : a primer -- Introduction to human health risk assessment -- Practical considerations for the application of toxicogenomics to risk assessment--early experience, current drivers, and a path forward -- Approaches and practical considerations for the analysis of toxicogenomics data -- Genomics in identifying mutagenic mode of action in carcinogenesis -- Application of genomics for predicting and understanding the mode of action for non-genotoxic carcinogens -- Genomics in characterizing endocrine toxicity -- Studying organ specific toxicity using gene expression profiling -- Toxicogenomic studies in human populations -- Toxicogenomics applied to ecological risk assessment -- Analysis of transcriptomic dose response data for toxicology and risk assessment -- Toxicogenomics as a tool for validating animal to human extrapolations in chemical risk assessment: concepts, applications and challenges -- Toxicogenomics and animal alternatives -- Toxicogenomics and the regulatory framework -- Standardization of gene expression information for the safety evaluation--activities in Japan -- -- Applying transcriptional profiling in drug safety evaluation -- Reframing the risk assessment paradigm : towards a systems biology approach. edited by Darrell R. Boverhof, B. Bhaskar Gollapudi. Includes bibliographical references and index. Genetic toxicology Toxicity testing Health risk assessment HEALTH & FITNESS Diseases Genetic MEDICAL Genetics Genetic toxicology Health risk assessment Toxicity testing Toxicogenetics Risk Assessment RA1224.3 .B68 2011eb 616/.042 QV 38 Hoboken, N.J. : John Wiley & Sons, ©2011 (DLC) 2010043286 (OCoLC)671385938 9781118001042 1118001044 9781118001035 1118001036 9781118008980 1118008987 10.1002/9781118001042 Wiley InterScience http://onlinelibrary.wiley.com/book/10.1002/9781118001042 http://onlinelibrary.wiley.com/book/10.1002/9781118001042 DG1 110811 20171116135919.0 ocn746321023 eng