05215cam a2200793Ia 4500 ocn746321023 OCoLC 20171116135919.0 m o d cr cn||||||||| 110811s2011 njua ob 001 0 eng d 2010043286 9781118001042 (electronic bk.) 1118001044 (electronic bk.) 9781118001035 (electronic bk.) 1118001036 (electronic bk.) 9781118008980 (electronic bk.) 1118008987 (electronic bk.) 9780470449820 (cloth) 0470449829 (cloth) AU@ 000047980892 AU@ 000051555658 DEBBG BV043095691 DEBSZ 421535199 DEBSZ 430989636 DKDLA 820120-katalog:000557564 HEBIS 299830756 NZ1 14256978 DEBBG BV043393349 (OCoLC)746321023 (OCoLC)748534058 (OCoLC)756496448 (OCoLC)759159342 (OCoLC)811493622 (OCoLC)832589834 (OCoLC)860516526 (OCoLC)961549081 (OCoLC)962639971 (OCoLC)966261537 10.1002/9781118001042 Wiley InterScience http://www3.interscience.wiley.com DG1 eng pn DG1 YDXCP IDEBK OCLCQ N$T E7B OCLCO OCLCQ WAU OCLCF OCLCQ NLGGC NLE DEBSZ MHW UKDOC K6U OCLCQ EBLCP OCLCQ DEBBG D6H AZK LOA OCLCO JBG OCLCO OCLCA MAIN RA1224.3 .B68 2011eb QV 38 HEA 039060 bisacsh MED 107000 bisacsh 616/.042 22 Applications of toxicogenomics in safety evaluation and risk assessment / edited by Darrell R. Boverhof, B. Bhaskar Gollapudi. [electronic resource] Hoboken, N.J. : John Wiley & Sons, ©2011. 1 online resource (xiii, 377 pages) : illustrations text txt rdacontent computer c rdamedia online resource cr rdacarrier data file rda Bibliography Includes bibliographical references and index. Toxicology, "omics" technologies, and toxicogenomics : a primer -- Introduction to human health risk assessment -- Practical considerations for the application of toxicogenomics to risk assessment--early experience, current drivers, and a path forward -- Approaches and practical considerations for the analysis of toxicogenomics data -- Genomics in identifying mutagenic mode of action in carcinogenesis -- Application of genomics for predicting and understanding the mode of action for non-genotoxic carcinogens -- Genomics in characterizing endocrine toxicity -- Studying organ specific toxicity using gene expression profiling -- Toxicogenomic studies in human populations -- Toxicogenomics applied to ecological risk assessment -- Analysis of transcriptomic dose response data for toxicology and risk assessment -- Toxicogenomics as a tool for validating animal to human extrapolations in chemical risk assessment: concepts, applications and challenges -- Toxicogenomics and animal alternatives -- Toxicogenomics and the regulatory framework -- Standardization of gene expression information for the safety evaluation--activities in Japan -- -- Applying transcriptional profiling in drug safety evaluation -- Reframing the risk assessment paradigm : towards a systems biology approach. "This book provides a timely overview of toxicogenomics, with special emphasis on the practical applications of this technology to the risk assessment process. Introductory sections are followed by a series of chapters highlighting practical and systematic applications of toxicogenomics in informing the risk assessment process - including the areas of mutagenicity, carcinogenicity, endocrine toxicity, organ-specific toxicity, population monitoring, and ecotoxicology. The book concludes with approaches for the integration of this technology in safety evaluation studies, and an outlook on how toxicogenomics and complementary technologies can reframe the current risk assessment paradigm"--Provided by publisher. Print version record. Genetic toxicology. Toxicity testing. Health risk assessment. HEALTH & FITNESS Diseases Genetic. bisacsh MEDICAL Genetics. bisacsh Genetic toxicology. fast (OCoLC)fst00940097 Health risk assessment. fast (OCoLC)fst00953250 Toxicity testing. fast (OCoLC)fst01153336 Toxicogenetics. Risk Assessment. Electronic books. Electronic resource. Electronic books. local Boverhof, Darrell R. Gollapudi, B. Bhaskar. Print version: Applications of toxicogenomics in safety evaluation and risk assessment. Hoboken, N.J. : John Wiley & Sons, ©2011 9780470449820 (DLC) 2010043286 (OCoLC)671385938 http://onlinelibrary.wiley.com/book/10.1002/9781118001042 Wiley Online Library ddc BK 205186 205186