04887cam a2200661Ii 4500 ocn729726279 OCoLC 20171119083014.0 m o d cr cn||||||||| 110609s2011 gw a ob 001 0 eng d 9783527635955 (electronic bk.) 3527635955 (electronic bk.) 9783527635979 (electronic bk.) 3527635971 (electronic bk.) 1283140918 9781283140911 9783527326969 (hbk.) 3527326960 (hbk.) 9783527635962 3527635963 9783527635986 352763598X 9786613140913 AU@ 000047551108 NZ1 14693860 NZ1 15915098 (OCoLC)729726279 (OCoLC)740225701 (OCoLC)741454003 (OCoLC)778454561 (OCoLC)781264224 (OCoLC)785512762 (OCoLC)816845214 10.1002/9783527635955 Wiley InterScience http://www3.interscience.wiley.com DG1 eng rda pn DG1 YDXCP CDX OCLCQ E7B N$T SCB OCLCQ MHW OTZ IDEBK OCLCQ NLGGC OCLCQ COO OCLCQ TMC D6H MAIN RS431.A66 A68 2011 QV268.5 MED 071000 bisacsh 615.7924 22 Antiviral drug strategies / edited by Erik De Clercq. [electronic resource] Weinheim : Wiley-VCH ; Chichester : John Wiley [distributor], 2011. 1 online resource (xx, 406 pages) : illustrations (some color). text txt rdacontent computer c rdamedia online resource cr rdacarrier Methods and principles in medicinal chemistry ; v. 50 Includes bibliographical references and index. Outlook of the antiviral drug era, now more than 50 years after description of the first antiviral drug / Erik De Clercq -- Inhibition of HIV entry / José A. Esté -- Targeting integration beyond strand transfer: development of second-generation HIV integrase inhibitors / Arnout R.D. Voet, Marc De Maeyer, Frauke Christ, Zeger Debyser -- From saquinavir to darunavir: the impact of 10 years of medicinal chemistry on a lethal disease / Marie-Pierre de Béthune, Anik Peeters, Piet Wigerinck -- Acyclic and cyclic nucleoside phosphonates / Richard L. Mackman, Tomas Cihlar -- Helicase-primase inhibitors: a new approach to combat herpes simplex virus and varicella zoster virus / Subhajit Biswas, Hugh J. Field -- Cyclophilin inhibitors / Grégoire Vuagniaux, Arnaud Hamel, Rafael Crabbé, Hervé C. Porchet, Jean-Maurice Dumont -- Alkoxyalkyl ester prodrugs of antiviral nucleoside phosphates and phosphonates / James R. Beadle, Karl Y. Hostetler -- Maribavir: a novel benzimidazole ribonucleoside for the prevention and treatment of cytomegalovirus diseases / Karen K. Biron -- Anti-HCMV compounds / Graciela Andrei, Robert Snoeck -- Lethal mutagenesis as an unconventional approach to combat HIV / Pinar Iyidogan, Karen S. Anderson -- Recent progress in the development of HCV protease inhibitors / Nagraj Mani, Bhisetti G. Rao, Tara L. Kieffer, Ann D. Kwong -- Antiviral RNAi: how to silence viruses / Karin J. von Eije, Ben Berkhout -- Neuraminidase inhibitors as anti-influenza agents / Willard Lew, Michael Z. Wang, Xiaowu Chen, James F. Rooney, Choung Kim -- From TIBO to rilpivirine: the chronicle of the discovery of the ideal nonnucleoside reverse transcriptase inhibitor / Erik De Clercq. By focusing on general molecular mechanisms of antiviral drugs rather than therapies for individual viruses, this ready reference provides the critical knowledge needed to develop entirely novel therapeutics and to target new viruses. It begins with a general discussion of antiviral strategies, followed by a broad survey of known viral targets, such as reverse transcriptases, proteases, neuraminidases, RNA polymerases, helicases and primases, as well as their known inhibitors. The final section contains several cases studies of recent successful antiviral drug development. Edited by Erik de. Print version record. Antiviral agents Development. Antiviral agents Development. MEDICAL Pharmacology. bisacsh Antiviral Agents. Drug Discovery. Electronic books. De Clercq, Erik. Print version: Antiviral drug strategies. Weinheim : Wiley-VCH ; Chichester : John Wiley [distributor], 2011 9783527326969 (OCoLC)664325845 Methods and principles in medicinal chemistry ; v. 50. http://onlinelibrary.wiley.com/book/10.1002/9783527635955 Wiley Online Library ddc BK 205122 205122