04338cam a2200685Ka 4500 ocn729724693 OCoLC 20171119081024.0 m o d cr cn||||||||| 110609s2011 gw a ob 001 0 eng d 9783527633470 (electronic bk.) 3527633472 (electronic bk.) 9783527633487 (electronic bk.) 3527633480 (electronic bk.) 1283283247 9781283283243 9783527317905 3527317902 9786613283245 AU@ 000049641601 GBVCP 790033518 NZ1 15916500 DEBBG BV043393179 (OCoLC)729724693 (OCoLC)756898492 (OCoLC)757403635 (OCoLC)759006763 (OCoLC)816865413 10.1002/9783527633470 Wiley InterScience http://www3.interscience.wiley.com DG1 eng pn DG1 YDXCP N$T CDX OCLCQ OCLCO OCLCQ UWO OCLCQ OCLCA NLGGC IDEBK OCLCQ DEBBG MAIN RM666.E548 P76 2011 W1 ME9613H v.49 2011 QU 143 MED 071000 bisacsh TDCW bicssc 615.798 22 Protein kinases as drug targets / edited by Bert Klebl, Gerhard Müller, and Michael Hamacher. [electronic resource] Weinheim : Wiley-VCH ; Chichester : John Wiley [distributor], ©2011. 1 online resource (xxi, 373 pages) : illustrations (some color). text txt rdacontent computer c rdamedia online resource cr rdacarrier Methods and principles in medicinal chemistry ; 49 Includes bibliographical references and index. In vitro characterization of small-molecule kinase inhibitors -- Screening for kinase inhibitors: from biochemical to cellular assays -- Dissecting phosphorylation networks: the use of analogue-sensitive kinases and more specific kinase inhibitors as tools -- Rational drug design of kinase inhibitors for signal transduction therapy -- Kinaes inhibitors in signal transduction therapy -- Design principles of deep pocket-targeting protein kinase inhibitors -- From discovery to clinic: aurora kinase inhibitors as novel treatments for cancer -- Discovery and design of protein kinase inhibitors: targeting the cell cycle in oncology -- Medicinal chemistry approaches for the inhibition of the p38 MAPK pathway -- Cellular protein kinases as antiviral targets -- Prospects for TB therapeutics targeting mycobacterium tuberculosis phosphosignaling networks. With Kinase inhibitors being widely seen as the long-sought 'magic bullet' to conquer cancer, this fully comprehensive guide to kinase inhibitor drug development covers the entire drug pipeline from target identification to compound development and clinical application. Volume 1 focuses upon the medicinal chemistry of kinase drugs, from target identification to lead optimization, and contains numerous contributions from large and small pharmaceutical companies. Volume 2 surveys current and future therapeutic application areas for kinase inhibitor drugs, with a strong focus on oncology drugs, as this is the most important therapeutic field for these drugs. In addition, all six currently approved kinase inhibitor drugs (small molecules and antibodies) are described, and their performances in clinical practice are discussed. Print version record. Protein kinases Inhibitors. Antineoplastic agents Development. Protein Kinase Inhibitors therapeutic use. Drug Delivery Systems. Drug Discovery. MEDICAL Pharmacology. bisacsh Electronic books. Müller, Gerhard. Klebl, Bert. Wiley InterScience (Online service) Print version: Protein kinases as drug targets. Weinheim : Wiley-VCH ; Chichester : John Wiley [distributor], ©2011 9783527317905 (OCoLC)664325820 Methods and principles in medicinal chemistry ; 49. http://onlinelibrary.wiley.com/book/10.1002/9783527633470 Wiley Online Library ddc BK 205092 205092