05853cam a2200577Ia 4500 ocn716174431 OCoLC 20171119092558.0 m o d cr cn||||||||| 110428s2011 enk o 001 0 eng d 9780470979624 (electronic bk.) 0470979623 (electronic bk.) 1283374056 9781283374057 AU@ 000047158761 DEBBG BV041900813 GBVCP 790033127 NZ1 15900651 (OCoLC)716174431 (OCoLC)711782138 (OCoLC)772397964 (OCoLC)816879083 10.1002/9780470979624 Wiley InterScience http://www3.interscience.wiley.com UIU eng pn UIU DG1 YDXCP OCLCQ IDEBK OCLCQ OCLCA STF OCLCA OCLCF OCLCO NLGGC DEBBG OCLCQ MAIN QP363.5 .B85 2011 WL 102.5 PS bicssc 612.8 22 Building brains : an introduction to neural development / David Price [and others]. [electronic resource] Chichester, UK : John Wiley & Sons, 2011. 1 online resource text txt rdacontent computer c rdamedia online resource cr rdacarrier Front Matter -- Models and Methods for Studying Neural Development -- The Anatomy of Developing Nervous Systems -- Neural Induction: An Example of How Intercellular Signalling Determines Cell Fates -- Patterning the Neuroectoderm -- Neurogenesis: Generating Neural Cells -- Neuronal Migration -- How Neurons Develop Their Shapes -- Axon Guidance -- Map Formation -- Maturation of Functional Properties -- Life and Death in the Developing Nervous System -- Experience-Dependent Development -- Suggestions for Further Reading -- Glossary -- Index. Models and methods for studying neural development -- The anatomy of developing nervous systems -- Neural induction : an early example of how intercellular signalling determines cell fates -- Patterning the neuroectoderm -- Neurogenesis : generating neural cells -- Neuronal migration -- How neurons develop their shapes -- Axon pathfinding : the long and winding road -- Map formation -- Maturation of functional properties -- Life and death in the developing nervous system -- Experience-dependent development. The development of a brain from its simple beginnings in the embryo to the extraordinarily complex fully-functional adult structure is a truly remarkable process. Understanding how it occurs remains a formidable challenge despite enormous advances over the last century and current intense world-wide scientific research. A greater knowledge of how nervous systems construct themselves will bring huge benefits for human health and future technologies. Unravelling the mechanisms that lead to the development of healthy brains should help scientists tackle currently incurable diseases of the nervous system such as autism, epilepsy and schizophrenia (to name but a few), discover more about the processes that cause the uncontrolled growth associated with cancer and develop possible treatments. Building Brains provides a highly visual and readily accessible introduction to the main events that occur during neural development and the mechanisms by which they occur. Aimed at undergraduate students and postgraduates new to the field, who may not have a background in neuroscience and/or molecular genetics, it explains how cells in the early embryo first become neural, how their proliferation is controlled, what regulates the types of neural cells they become, how neurons connect to each other, how these connections are later refined under the influence of neural activity including that arising from experience, and why some neurons normally die. Key Features: A concise illustrated guide focusing on the core elements of current understanding of neural development, emphasising common principles underlying developmental mechanisms and supplemented by suggestions for further reading. Text boxes throughout provide further detail on selected major advances, issues of particular uncertainty or controversy and examples of human diseases that result from abnormal development. A balanced mammalian/non-mammalian perspective, drawing on examples from model organisms including the fruit fly, nematode worm, frog, zebrafish, chick, mouse, ferret, cat, monkey and human, and emphasising mechanisms that are conserved across species. Introduces the methods for studying neural development including genetics, transgenic technologies, advanced microscopy and computational modeling, allowing the reader to understand the main evidence underlying research advances. Student-friendly, full colour artwork reinforces important concepts; an extensive glossary and definitions in page margins help readers from different backgrounds; chapter summaries stress important points and aid revision. Associated Website includes a complete set of figures from the textbook. Print version record. Developmental neurobiology. Nervous system Growth. Neurons physiology. Nervous System anatomy & histology. Neurogenesis. Developmental neurobiology. fast (OCoLC)fst00891810 Nervous system Growth. fast (OCoLC)fst01036128 Electronic books. Price, David J., 1957 November 20- Wiley InterScience (Online service) Print version: Building brains. Chichester, UK : John Wiley & Sons, 2011 9780470712306 (DLC) 2010053724 (OCoLC)694600455 http://onlinelibrary.wiley.com/book/10.1002/9780470979624 Wiley Online Library ddc BK 205016 205016