Prodrugs and Targeted Delivery : Towards Better ADME Properties / [electronic resource] Rautio, Jarkko. Mannhold, Raimund, 1948- Kubinyi, Hugo. Wiley InterScience (Online service) Prodrugs. Pharmacy. Medicine. Prodrugs. Drug Delivery Systems. RM301.57 .P76 2011eb 615.191 22 Includes bibliographical references (pages 473-481) and index. Print version record. This topical reference and handbook addresses the chemistry, pharmacology, toxicology and the patentability of prodrugs, perfectly mirroring the integrated approach prevalent in today's drug design. It summarizes current experiences and strategies for the rational design of prodrugs, beginning at the early stages of the development process, as well as discussing organ- and site-selective prodrugs. Every company employing medicinal chemists will be interested in this practice-oriented overview of a key strategy in modern drug discovery and development. Weinheim : Wiley-VCH, ©2011. ©2011. 2011 Text 1 online resource (522 pages). http://onlinelibrary.wiley.com/book/10.1002/9783527633166 eng Methods and Principles in Medicinal Chemistry ; [47] Methods and principles in medicinal chemistry. Prodrugs and Targeted Delivery. Prodrugs and Targeted Delivery.