05365cam a2200457Ka 4500 ocn705353479 OCoLC 20171119104803.0 m o d cr cn||||||||| 110304s2011 gw ob 001 0 eng d 9783527633883 (electronic bk.) 352763388X (electronic bk.) AU@ 000047226206 GBVCP 790032708 NZ1 14971695 DEBBG BV043392837 (OCoLC)705353479 (OCoLC)716215524 10.1002/9783527633883 Wiley InterScience http://www3.interscience.wiley.com DG1 eng DG1 UIU YDXCP OCLCQ OCLCA OCLCQ MAIN QR189.5.P76 A65 2011 615.792 22 Apicomplexan parasites : molecular approaches toward targeted drug development / [electronic resource] Weinheim : Wiley-VCH ; Chichester : John Wiley [distributor], 2011. pages cm. text txt rdacontent computer c rdamedia online resource cr rdacarrier Drug discovery in infectious diseases Includes bibliographical references and index. Front Matter -- Screening, Bioinformatics, Chemoinformatics, and Drug Design. Drug Discovery Approaches toward Anti-Parasitic Agents / Andreas Rohwer, Richard J Marh̲fer, Conor R Caffrey, Paul M Selzer -- New Bioinformatic Strategies against Apicomplexan Parasites / Thomas Dandekar, Ke Xiao -- Sorting Potential Therapeutic Targets in Apicomplexa / Jan A Hiss, Gisbert Schneider -- Alternatives to Drug Development in the Apicomplexa / Theo P M Schetters -- Metabolic Pathways and Processes Addressed by Current Drug Discovery Approaches. Energy Metabolism as an Antimalarial Drug Target / Esther Jortzik, Katja Becker -- Polyamines in Apicomplexan Parasites / Ingrid B Muller, Robin Das Gupta, Kai Luersen, Carsten Wrenger, Rolf D Walter -- The Reducing Milieu of Parasitized Cells as a Target of Antimalarial Agents: Methylene Blue as an Ethical Drug / Peter Meissner, Heike Adler, Denis Kasozi, Karin Fritz-Wolf, R Heiner Schirmer -- Lipids as Drug Targets for Malaria Therapy / Henri J Vial, Diana Penarete, Sharon Wein, Sergio Caldarelli, Laurent Fraisse, Suzanne Peyrottes -- Targeting Apicoplast Pathways in / Snober S Mir, Subir Biswas, Saman Habib -- Lipoic Acid Acquisition and Glutathione Biosynthesis in Apicomplexan Parasites / Janet Storm, Eva-Maria Patzewitz, Sylke Muller -- Antimalarial Drugs and Molecules Inhibiting Hemozoin Formation / Uday Bandyopadhyay, Sumanta Dey -- Exploiting the Vitamin Metabolism of Apicomplexa as Drug Targets / Carsten Wrenger, Ingrid B Muller -- Vitamin Biosynthetic Pathways, the PLP Synthase Complex, and the Potential for Targeting Protein₆Protein Interaction / Ivo Tews, Irmgard Sinning -- Targeting Prokaryotic Enzymes in the Eukaryotic Pathogen / Suresh Kumar Gorla, Corey Johnson, Jihan Khan, Xin Sun, Lisa Sharling, Boris Striepen, Lizbeth Hedstrom -- Drug Targets in Apicomplexan Parasites. Novel Apicomplexan Phosphatases and Immunophilins as Domain-Specific Drug Targets / Sailen Barik -- Dehydrogenases and Enzymes of the Mitochondrial Electron Transport Chain as Anti-Apicomplexan Drug Targets / Kathleen Zocher, Stefan Rahlfs, Katja Becker -- Calcium-Dependent Protein Kinases as Drug Targets in Apicomplexan Parasites / Dominik Kugelstadt, Bianca Derrer, Barbara Kappes -- Protein Acylation: New Potential Targets for Intervention against the Apicomplexa / Joana M Santos, Christian Hedberg, Dominique Soldati-Favre -- Drugs and Drug Targets in and Related Apicomplexans / Joachim Muller, Norbert Muller, Andrew Hemphill -- Compounds. Subversive Substrates of Glutathione Reductases from -Infected Red Blood Cells as Antimalarial Agents / Elisabeth Davioud-Charvet, Don Antoine Lanfranchi -- Ferroquine: A Concealed Weapon / Christophe Biot, Bruno Pradines, Daniel Dive -- Current Aspects of Endoperoxides in Antiparasitic Chemotherapy / Denis Matovu Kasozi, Stefan Rahlfs, Katja Becker -- Hsp90 as an Antimalarial Target / G Sridhar Prasad, Nicholas D P Cosford, Sailen Barik -- Drug Discovery against and / Mohamad Alaa Terkawi, Ikuo Igarashi -- Search for Drugs and Drug Targets against, and () / Sabine Bork-Mimm -- Orlistat: A Repositioning Opportunity as a Growth Inhibitor of Apicomplexan Parasites? / Christian Miculka, Hon Q Tran, Thorsten Meyer, Anja R Heckeroth, Stefan Baumeister, Frank Seeber, Paul M Selzer -- Recent Drug Discovery against / Jean-Fraṅois Rossignol, J Edward Semple, Andrew V Stachulski, Gilles Gargala. Electronic reproduction. Hoboken, N.J. : Wiley InterScience, 2011. Mode of access: World Wide Web. System requirements: Web browser. Title from title screen (viewed on Mar. 2, 2011). Access may be restricted to users at subscribing institutions. Protozoan vaccines Development. Apicomplexa. Electronic books. Wiley InterScience (Online service) Print version: Apicomplexan parasites. Weinheim : Wiley-VCH ; Chichester : John Wiley [distributor], 2011 9783527327317 (OCoLC)664325849 http://onlinelibrary.wiley.com/book/10.1002/9783527633883 Wiley Online Library ddc BK 204925 204925