Wang, Minghan 1966- text bibliography Electronic books. Elektronische boeken. Electronic books. nju Hoboken, N.J John Wiley & Sons ©2011 2011 monographic eng

electronic resource

1 online resource (xiii, 494 pages) : illustrations This book provides a comprehensive overview of the development of metabolic syndrome, the underlying mechanisms and therapeutic strategies for drug development. The authors examine the context of underlying molecular pathways and integrated physiology, then expanding the discussion to diseases associated with metabolic syndrome. The development of drug therapies for these diseases and complications is extensively covered. The book offers a comprehensive and in-depth view of energy metabolism, metabolic tissues and pathways, molecular mechanism-based drug discovery and clinical implications. Gut as an endocrine organ : the role of nutrient-sensing in energy metabolism / Minghan Wang -- Central glucose sensing and control of food intake and energy homeostasis / Lourdes Mounien and Bernard Thorens -- Abnormalities in insulin secretion in type 2 diabetes mellitus / Taly Meas and Pierre-Jean Guillausseau -- Adipokine production by adipose tissue : a novel target for treating metabolic syndrome and its sequelae / Vanessa DeClercq [and others] -- Hepatic metabolic dysfunctions in type 2 diabetes : insulin resistance and impaired glucose production and lipid synthesis / Ruojing Yang -- Energy metabolism in skeletal muscle and its link to insulin resistance / Minghan Wang -- Mechanisms and complications of metabolic syndrome / Minghan Wang -- Emerging therapeutic approaches for dyslipidemias associated with high LDL and low HDL / Margrit Schwarz and Jae B. Kim -- Mechanism of action of niacin : implications for atherosclerosis and drug discovery / Devan Marar [and others] -- Current anti-diabetic therapies and mechanisms / Minghan Wang -- GLP-1 biology, signaling mechanisms, physiology, and clinical studies / Remy Burcelin [and others] -- Dipeptidyl peptidase IV inhibitors for treatment of diabetes / C.H.S. McIntosh [and others] -- Sodium glucose co-transporter 2 inhibitors / Margaret Ryan and Serge A. Jabbour -- Fibroblast growth factor 21 as a novel metabolic regulator / Radmila Micanovic, James D. Dunbar, and Alexei Kharitonenkov -- Sirtuins as potential drug targets for metabolic diseases / Qiang Tong -- 11[beta]-hydroxysteroid dehydrogenase type 1 as a therapeutic target for type 2 diabetes / Clarence Hale and David J. St. Jean, Jr. -- Monoclonal antibodies for the treatment of type 2 diabetes : a case study with glucagon receptor blockade / Hai Yan, Wei Gu, and Murielle Veniant-Ellison -- Drug development for metabolic diseases: past, present and future / Minghan Wang. edited by Minghan Wang. Includes bibliographical references and index. Metabolic syndrome Pathophysiology Metabolic syndrome Chemotherapy Metabolic Syndrome X drug therapy Metabolic Syndrome X physiopathology Metabolic syndrome Chemotherapy Metabolic syndrome Pathophysiology MEDICAL Endocrinology & Metabolism MEDICAL Nutrition Stofwisselingsziekten Endocrinologie RC662.4 .M53 2011eb 616.3/99 WK 820 M58695 2011 44.87 44.89 Hoboken, N.J. : John Wiley & Sons, ©2011 (DLC) 2010019505 (OCoLC)614271402 9780470910009 0470910003 9780470910016 0470910011 288898 MIL http://onlinelibrary.wiley.com/book/10.1002/9780470910016 http://onlinelibrary.wiley.com/book/10.1002/9780470910016 N$T 110111 20171119104736.0 ocn696237308 eng