05382cam a2200757Ka 4500 ocn696237308 OCoLC 20171119104736.0 m o d cr cnu---unuuu 110111s2011 njua ob 001 0 eng d 2010019505 9780470910009 (electronic bk.) 0470910003 (electronic bk.) 9780470910016 0470910011 9780470343425 0470343427 9786612888984 AU@ 000047551138 AU@ 000053277718 DKDLA 820120-katalog:000557278 GBVCP 790033046 HEBIS 299817733 NLGGC 332403440 NZ1 14255833 NZ1 15915918 (OCoLC)696237308 (OCoLC)702844251 (OCoLC)714798766 (OCoLC)761006886 (OCoLC)811498346 (OCoLC)816616215 (OCoLC)860517764 (OCoLC)961515312 (OCoLC)962635572 (OCoLC)966258890 288898 MIL N$T eng pn N$T CDX YDXCP E7B OCLCQ OCLCO OCLCQ NLGGC MHW OCLCQ NLE IDEBK OCLCQ NKT DG1 OCLCQ AZK DG1 LOA OCLCO OCLCA MAIN RC662.4 .M53 2011eb WK 820 M58695 2011 MED 027000 bisacsh MED 060000 bisacsh 616.3/99 22 44.87 bcl 44.89 bcl Metabolic Syndrome : edited by Minghan Wang. [electronic resource] Hoboken, N.J. : John Wiley & Sons, ©2011. 1 online resource (xiii, 494 pages) : illustrations text txt rdacontent computer c rdamedia online resource cr rdacarrier Includes bibliographical references and index. Gut as an endocrine organ : the role of nutrient-sensing in energy metabolism / Minghan Wang -- Central glucose sensing and control of food intake and energy homeostasis / Lourdes Mounien and Bernard Thorens -- Abnormalities in insulin secretion in type 2 diabetes mellitus / Taly Meas and Pierre-Jean Guillausseau -- Adipokine production by adipose tissue : a novel target for treating metabolic syndrome and its sequelae / Vanessa DeClercq [and others] -- Hepatic metabolic dysfunctions in type 2 diabetes : insulin resistance and impaired glucose production and lipid synthesis / Ruojing Yang -- Energy metabolism in skeletal muscle and its link to insulin resistance / Minghan Wang -- Mechanisms and complications of metabolic syndrome / Minghan Wang -- Emerging therapeutic approaches for dyslipidemias associated with high LDL and low HDL / Margrit Schwarz and Jae B. Kim -- Mechanism of action of niacin : implications for atherosclerosis and drug discovery / Devan Marar [and others] -- Current anti-diabetic therapies and mechanisms / Minghan Wang -- GLP-1 biology, signaling mechanisms, physiology, and clinical studies / Remy Burcelin [and others] -- Dipeptidyl peptidase IV inhibitors for treatment of diabetes / C.H.S. McIntosh [and others] -- Sodium glucose co-transporter 2 inhibitors / Margaret Ryan and Serge A. Jabbour -- Fibroblast growth factor 21 as a novel metabolic regulator / Radmila Micanovic, James D. Dunbar, and Alexei Kharitonenkov -- Sirtuins as potential drug targets for metabolic diseases / Qiang Tong -- 11[beta]-hydroxysteroid dehydrogenase type 1 as a therapeutic target for type 2 diabetes / Clarence Hale and David J. St. Jean, Jr. -- Monoclonal antibodies for the treatment of type 2 diabetes : a case study with glucagon receptor blockade / Hai Yan, Wei Gu, and Murielle Veniant-Ellison -- Drug development for metabolic diseases: past, present and future / Minghan Wang. This book provides a comprehensive overview of the development of metabolic syndrome, the underlying mechanisms and therapeutic strategies for drug development. The authors examine the context of underlying molecular pathways and integrated physiology, then expanding the discussion to diseases associated with metabolic syndrome. The development of drug therapies for these diseases and complications is extensively covered. The book offers a comprehensive and in-depth view of energy metabolism, metabolic tissues and pathways, molecular mechanism-based drug discovery and clinical implications. Print version record. Metabolic syndrome Pathophysiology. Metabolic syndrome Chemotherapy. Metabolic Syndrome X drug therapy. Metabolic Syndrome X physiopathology. Metabolic syndrome Chemotherapy. Metabolic syndrome Pathophysiology. MEDICAL Endocrinology & Metabolism. bisacsh MEDICAL Nutrition. bisacsh Stofwisselingsziekten. gtt (NL-LeOCL)078677408 Endocrinologie. gtt (NL-LeOCL)078497108 Electronic books. Elektronische boeken. gtt (NL-LeOCL)303983256 Electronic books. local Wang, Minghan, 1966- Print version: Metabolic syndrome. Hoboken, N.J. : John Wiley & Sons, ©2011 9780470343425 (DLC) 2010019505 (OCoLC)614271402 http://onlinelibrary.wiley.com/book/10.1002/9780470910016 Wiley Online Library ddc BK 204884 204884